Acute dietary nitrate supplementation does not change venous volume and compliance in healthy young adults
Acute dietary nitrate supplementation does not change venous volume and compliance in healthy young adults
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急性膳食硝酸盐补充剂不会改变健康年轻人的静脉容量和顺应性
DOI：
10.1152/ajpregu.00083.2022
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ota Masako
中科院分区：
文献类型：
--
作者：
Oue Anna;Iimura Yasuhiro;Shinagawa Akiho;Miyakoshi Yuichi;Ota Masako
在这项交叉研究中，我们研究了补充无机硝酸盐对静息前臂和小腿静脉容量和顺应性的影响。20名健康的年轻人被分配接受一种富含饮料[甜菜根汁（BRJ）： 140毫升；1 ~ 8 mmol]或无对照饮料[西梅汁（CON）： 166 mL；< 0.01 mmol)。饮用分配的饮料2小时后，每个参与者仰卧休息20分钟。然后将袖带环绕右上臂和右大腿，充气至60 mmHg 8分钟，然后以1 mmHg/s的速度降至0 mmHg。在袖带压力膨胀和收缩期间，通过静脉闭塞容积描记术测量前臂和小腿静脉体积的变化。静脉顺应性计算为四肢袖带压力-静脉容积曲线的数值导数。摄入BRJ后血浆浓度升高（前15.5±5.8µM，后572.0±116.1µM，P< 0.05）， CON无升高（前14.8±7.2µM，后15.3±7.4µM，P< 0.05）。另一方面，BRJ和con在前臂和小腿静脉容量和顺应性方面没有显著差异。这些研究结果表明，尽管急性无机NO3−补充可能通过亚硝酸盐→no途径增强一氧化氮（no）的活性，但它不会影响健康年轻人四肢静脉容量和顺应性。
In this crossover study, we investigated the influence of inorganic nitrate () supplementation on venous volume and compliance in the resting forearm and calf. Twenty healthy young adults were assigned to receive an-rich beverage [beetroot juice (BRJ): 140 mL; ∼8 mmol] or an-depleted control beverage [prune juice (CON): 166 mL; < 0.01 mmol). Two hours after consuming the allocated beverage, each participant rested in the supine position for 20 min. Cuffs were then placed around the right upper arm and right thigh, inflated to 60 mmHg for 8 min, and then decreased to 0 mmHg at a rate of 1 mmHg/s. During inflation and deflation of cuff pressure, changes in venous volume in the forearm and calf were measured by venous occlusion plethysmography. Venous compliance was calculated as the numerical derivative of the cuff pressure-venous volume curve in the limbs. The plasmaconcentration was elevated by intake of BRJ (before, 15.5 ± 5.8 µM; after, 572.0 ± 116.1 µM,P< 0.05) but not by CON (before, 14.8 ± 7.2 µM; after, 15.3 ± 7.4 µM,P> 0.05). On the other hand, there was no significant difference in venous volume or compliance in the forearm or calf between BRJ and CON. These findings suggest that although acute inorganic NO3−supplementation may enhance the activity of nitric oxide (NO) via nitrite → NO pathway, it does not influence venous volume or compliance in the limbs in healthy young adults.