Metal organic framework ZIF-90 modified with lactobionic acid for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs
Metal organic framework ZIF-90 modified with lactobionic acid for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs
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DOI：
10.1007/s00604-020-04611-1
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发表时间：
2020-11-11
影响因子：
5.7
通讯作者：
Ma, Xiaofei
中科院分区：
文献类型：
--
作者：
Ding, Wen;Ma, Mingxuan;Ma, Xiaofei
采用溶剂热合成法制备了原位分子筛咪唑金属有机骨架90（ZIF-90）修饰毛细管。通过扫描电子显微镜、能量色散X射线光谱仪和X射线衍射仪对ZIF-90涂层进行了表征。以乳糖酸（LA）为手性选择剂，采用毛细管电色谱法对基础药物普萘洛尔（PRO）、美托洛尔（MET）、阿替洛尔（ATE）、比索洛尔（BIS）和索他洛尔（SOT）进行了手性拆分。与未涂层石英毛细管相比，分辨率大大提高（PRO 1.40 -> 3.23; MET 1.07 -> 3.19; ATE 1.07 -> 3.15; BIS 1.16 -> 3.41; SOT 1.00 -> 2.79）。考察了缓冲液pH值、有机添加剂比例、乳糖酸浓度和外加电压等因素的影响。
An in situ zeolite imidazole metal organic framework-90 (ZIF-90) modified capillary was prepared via the method of solvothermal synthesis. The coating of ZIF-90 was characterized by scanning electron microscopy, energy-dispersive X-ray spectrometry, and EOF. Capillary electrochromatography-based enantioseparation of the basic drugs propranolol (PRO), metoprolol (MET), atenolol (ATE), bisoprolol (BIS), and sotalol (SOT) was performed using lactobionic acid (LA) as the chiral selector. Compared with an uncoated silica capillary, the resolutions are greatly improved (PRO 1.40 -> 3.23; MET 1.07 -> 3.19; ATE 1.07 -> 3.15; BIS 1.16 -> 3.41; SOT 1.00 -> 2.79). Effects of buffer pH values, proportion of organic additives, concentration of lactobionic acid, and applied voltage were investigated.