ETHANOL-INDUCED SLEEP TIME - INTERACTION WITH TAURINE AND A TAURINE ANTAGONIST
ETHANOL-INDUCED SLEEP TIME - INTERACTION WITH TAURINE AND A TAURINE ANTAGONIST
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DOI：
10.1016/0091-3057(87)90564-8
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发表时间：
1987-06-01
影响因子：
3.6
通讯作者：
FERKO, AP
中科院分区：
文献类型：
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作者：
FERKO, AP
在雄性Swiss-Webster小鼠中，睡眠时间（催眠）被用作乙醇诱导的中枢神经系统抑郁的指标。向动物给予乙醇（4 g/kg，IP），并记录入睡时间（翻正反射丧失）和睡眠持续时间。在乙醇诱导的睡眠时间结束时，注射牛磺酸（7.5、15或25 μ mol/kg，ICV）。IVC注射牛磺酸后，小鼠立即再次失去翻正反射。牛磺酸的这种作用呈剂量依赖性。在不存在乙醇的情况下，牛磺酸（25 μ mol/kg，ICV）不产生显著的睡眠时间。在另一个实验中，当将TAG，6-氨基-甲基-3-4H-1，3，4-苯并噻二嗪-1，1-二氧化物盐酸盐（牛磺酸拮抗剂）给予小鼠时，TAG（0.9 μ mol/kg，ICV）显著降低了牛磺酸（7.5、15和25 μ mol/kg，ICV）在乙醇存在下恢复睡眠时间的作用。然而，TAG并没有改变乙醇诱导的睡眠时间。这些结果表明，牛磺酸（ICV）可增强乙醇的中枢兴奋作用，而TAG可减弱牛磺酸的这种作用。TAG对牛磺酸的拮抗作用似乎是非竞争性的。
In male Swiss-Webster mice sleep time (hypnosis) was used as an index of ethanol-induced central nervous system depression. Ethanol (4 g/kg, IP) was administered to animals and the onset to sleep time (loss of the righting reflex) and the duration of sleep time were recorded. At the end of the ethanol-induced sleep time, taurine (7.5, 15 or 25 .mu.mol/kg, ICV) was injected. Immediately after the IVC injection of taurine the mice again lost the righting reflex. This effect of taurine occurred in a dose-dependent fashion. In the absence of ethanol, taurine (25 .mu.mol/kg, ICV) did not produce a significant sleep time. In another experiment when TAG, 6-amino-methyl-3-4H-1,3,4-benzothiadiazine-1,1-dioxide HCl, (a taurine antagonist) was given to mice, TAG (0.9 .mu.mol/kg, ICV) significantly reduced the effect of taurine (7.5, 15 and 25 .mu.mol/kg, ICV) to reinstate a sleep time in the presence of ethanol. TAG, however, did not alter ethanol-induced sleep time. These results indicate that taurine (ICV) can enhance the central depressant action of ethanol and that this effect of taurine can be attenuated by TAG. The antagonism of taurine by TAG appears to be noncompetitive in nature.