Second-generation dimeric inhibitors of chitin synthase.
Second-generation dimeric inhibitors of chitin synthase.
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第二代几丁质合酶二聚体抑制剂。
DOI：
10.1016/j.bmc.2004.09.027
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Finney,NathanielS
中科院分区：
文献类型：
--
作者：
Yeager,AdamR;Finney,NathanielS
几丁质合成酶（Chitin synthase，CS）是真菌细胞壁生物合成所必需的，是一个很有吸引力的药物靶标。本文介绍了我们开发基于CS抑制剂机制的努力的扩展结果。具体而言，我们描述了尿苷二聚体连接的酒石酸酰胺作为潜在的焦磷酸盐模拟物。
Chitin synthase (CS) is essential for fungal cell wall biosynthesis and is an attractive medicinal target. Expanded results from our efforts to develop mechanism based inhibitors of CS are presented here. Specifically, we describe uridine dimers linked by tartrate amides as potential pyrophosphate mimics.