A new map to understand deubiquitination
A new map to understand deubiquitination
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DOI：
10.1042/bst0380021
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Crosas, Bernat
中科院分区：
文献类型：
--
作者：
Katz, Elijah J.;Isasa, Marta;Crosas, Bernat
去泛素化是泛素介导的信号转导网络中的一个重要机制。Dubs（去泛素化酶）作为不同细胞过程的调节剂的重要性越来越清楚，因为新的作用被阐明，新的途径被证明受到这种机制的影响。最近的工作，在本文件中回顾，Dubs和一个新的工具，不仅专注于Dubs相互作用的研究，但也可能有更多的细胞系统的影响扩大提供了新的视角。
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism. Recent work, reviewed in the present paper, provides new perspective on the widening influence of Dubs and a new tool to focus studies of not only Dub interactions, but also potentially many more cellular systems.