Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats.
Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats.
复制标题
DOI：
10.1100/tsw.2003.90
复制
发表时间：
2003-10-05
影响因子：
--
通讯作者：
Balasubramanian T
中科院分区：
文献类型：
--
作者：
Balasubramanian T
在长时间不进食的动物中，脂肪量下降到总体重的5%以下，导致血糖皮质激素和尿酸水平升高，随后是觅食活动。由于糖皮质激素增加了尿酸的排泄，膀胱尿液中尿酸水平的增加可能是这种进食行为和随后的脂肪储存的信号。脂肪的积累与代谢综合征或冬眠中出现的高血糖、高胰岛素、高脂血症和高胆固醇血症有关。据推测，尿酸或其结构相关化合物1-甲基尿酸（咖啡、茶、可可和某些药物中存在的甲基黄嘌呤即咖啡因、茶碱和可可碱的代谢物之一）可作用于膀胱粘膜，使血糖、胰岛素、甘油三酯和胆固醇水平升高。在大鼠中，与用蒸馏水灌注膀胱相比，用饱和尿酸水溶液或1-甲基尿酸灌注膀胱在20、40和80分钟时导致血清葡萄糖、胰岛素、真甘油三酯和总胆固醇水平显著升高。尿酸或1-甲基尿酸作用于膀胱粘膜，使血清葡萄糖、胰岛素、真甘油三酯和总胆固醇水平升高。
In animals deprived of food for a long period, a drop in the fat mass below 5% of the total body mass results in an increase in blood glucocorticoids and uric acid levels, followed by foraging activity. Since the glucocorticoids increase the uric acid excretion, an increase in the level of uric acid in the bladder urine could be the signal for this feeding behaviour and subsequent fat storage. Accumulation of fat is associated with hyperglycaemia, hyperinsulinaemia, hyperlipidaemia, and hypercholesterolaemia as seen in the metabolic syndrome or hibernation. It is hypothesized that uric acid or its structurally related compound, 1-methyl uric acid (one of the metabolites of the methyl xanthines namely caffeine, theophylline, and theobromine present in coffee, tea, cocoa, and some drugs), can act on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels. In rats, perfusion of the urinary bladder with saturated aqueous solution of uric acid or 1-methyl uric acid results in a significant increase in the serum levels of glucose, insulin, true triglyceride, and total cholesterol in comparison with perfusion of the bladder with distilled water at 20, 40, and 80 min. The uric acid or the 1-methyl uric acid acts on the urinary bladder mucosa and increases the serum glucose, insulin, true triglyceride, and total cholesterol levels.