A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine
A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine
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DOI：
10.1071/ch10201
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发表时间：
2010-01-01
影响因子：
1.1
通讯作者：
Willis, Anthony C.
中科院分区：
文献类型：
--
作者：
Banwell, Martin G.;Ma, Xinghua;Willis, Anthony C.
以易于获得的对映体纯的代谢物2为起始原料，实现了（+）-加兰他敏[（+）-1]的全合成。与靶1相关的季碳中心（C8 a）使用Rehenmoser-Claisen重排反应构建。
A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the Eschenmoser-Claisen rearrangement reaction.