Liver-specific deletion of TSHR inhibits hepatic lipid accumulation in mice
Liver-specific deletion of TSHR inhibits hepatic lipid accumulation in mice
复制标题
肝脏特异性删除 TSHR 可抑制小鼠肝脏脂质积累
DOI：
10.1016/j.bbrc.2018.01.187
复制
发表时间：
2018-02-26
影响因子：
3.1
通讯作者：
Chen, Shihong
中科院分区：
文献类型：
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作者：
Zhou, Lingyan;Wu, Kunpeng;Chen, Shihong
促甲状腺激素受体（TSHR）在体内对肝脏脂质蓄积的影响尚不完全清楚。此外，虽然甲状腺中的TSHR已被广泛研究，但肝脏中TSHR的缺乏是否以及如何影响全身能量代谢尚未报道。为了检查这些效果，我们使用Cre/LoxP重组技术产生肝TSHR条件性敲除（LT-KO）小鼠。肝脏特异性TSHR敲除（LT-KO）小鼠不仅表现出由于肝脏中脂质的合成和分解的改变而导致的肝脏甘油三酯和胆固醇含量降低，而且还表现出血清脂质，尤其是血清LDL-C水平降低。甲状腺中TSHR的缺失影响全身能量平衡;然而，在代谢室中进行的测量表明，肝脏TSHR条件性缺失对全身能量代谢没有影响。与维持甲状腺正常生长和功能的关键作用不同，我们的研究结果表明，肝脏TSHR参与肝脏脂质代谢，对能量代谢影响不大。(C)2018爱思唯尔公司All rights reserved.
The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effects, we generated hepatic TSHR conditional knockout (LT-KO) mice using Cre/LoxP recombination technology. The liver-specific TSHR-knockout (LT-KO) mice exhibited not only lower hepatic triglyceride and cholesterol contents due to modified synthesis and catabolism of lipids in the liver, but also decreased serum lipids, especially serum LDL-C levels. Abnormalities of TSHR in the thyroid affect whole body energy balance; however, measurements taken in metabolic chambers showed that the hepatic TSHR conditional deletion had no impact on systemic energy metabolism. Unlike its critical role in maintaining the normal growth and function of the thyroid gland, our results demonstrated that hepatic TSHR is involved in liver lipid metabolism and has little effect on energy metabolism. (C) 2018 Elsevier Inc. All rights reserved.