Serum low-density lipoprotein levels correlate with survival in advanced stage epithelial ovarian cancers.
Serum low-density lipoprotein levels correlate with survival in advanced stage epithelial ovarian cancers.
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DOI：
10.1016/j.ygyno.2009.09.027
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发表时间：
2010-01
影响因子：
4.7
通讯作者：
Karlan BY
中科院分区：
文献类型：
--
作者：
Li AJ;Elmore RG;Chen IY;Karlan BY
最近的数据表明，接受他汀类药物治疗的卵巢上皮癌患者的生存率有所提高。我们假设他汀类药物通过改变脂蛋白谱影响卵巢癌的预后，并试图确定脂蛋白水平与晚期卵巢癌患者生存率之间的相关性。在IRB批准后，我们确定了IIIC/IV期上皮性卵巢癌患者的诊断前空腹血清库。测定血清总胆固醇（TC）、高密度脂蛋白（HDL）和甘油三酯（TG）水平。通过从TC中减去TG/5和HDL计算LDL。使用Fisher精确、Kaplan-Meier和考克斯回归分析检查数据。研究了132例患者。26%的患者LDL升高; 18%的患者TC升高; 32%的患者TG升高; 48%的患者HDL升高。未发现TC、HDL、TG、LDL升高与年龄、IV期疾病、高级别或最佳细胞减灭术之间存在单变量相关性。LDL水平正常患者的中位无进展生存期为27个月，而LDL水平升高患者为12个月（p = 0.0004）。LDL水平正常的患者的总体疾病特异性生存期（59个月）长于LDL水平升高的患者（51个月，p = 0.04）。多变量分析表明，在控制了年龄、分期、分级和次优细胞减灭术后，LDL作为生存率的独立预测因子仍具有显著性（p = 0.003）。这些数据表明LDL是临床结果的重要预测因子，并保证了脂蛋白和他汀类药物对上皮性卵巢癌生物学的进一步研究。
Recent data suggest patients with epithelial ovarian cancers on statin therapy have improved survival. We have hypothesized that statins influence ovarian cancer outcome through alteration of lipoprotein profiles, and sought to determine correlations between lipoprotein levels and survival in women with advanced stage disease. After IRB approval, we identified patients with stage IIIC/IV epithelial ovarian cancer with banked prediagnostic fasting serum. Serum was assayed for levels of total cholesterol (TC), high-density lipoprotein (HDL), and triglycerides (TG). LDL was calculated by subtraction of TG/5 and HDL from TC. Data were examined using Fisher's exact, Kaplan–Meier, and Cox regression analyses. One hundred thirty-two patients were studied. Twenty-six percent of patients had elevated LDL; 18% had elevated TC; 32% had elevated TG; and 48% had elevated HDL. No univariate associations were identified between elevated TC, HDL, TG, LDL and age, stage IV disease, high grade, or optimal cytoreduction. Median progression-free survival for patients with normal LDL levels was 27 months, compared to 12 months for patients with elevated LDL (p = 0.0004). Overall disease-specific survival was longer for patients with normal LDL levels (59 months) compared to those with elevated LDL (51 months, p = 0.04). Multivariate analysis indicated that LDL retained significance as an independent predictor of survival, after controlling for age, stage, grade, and suboptimal cytoreduction (p = 0.003). These data suggest LDL is a significant predictor of clinical outcome, and warrant the further study of lipoproteins and statins on epithelial ovarian cancer biology.
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影响因子：
10.3
作者：
Platz, Elizabeth A.;Leitzmann, Michael F.;Giovannucci, Edward
通讯作者：
Giovannucci, Edward
影响因子：
3.8
作者：
Kwan, Marilyn L.;Habel, Laurel A.;Caan, Bette
通讯作者：
Caan, Bette
影响因子：
--
作者：
Ifere, Godwin O.;Barr, Erika;Ananaba, Godwin A.
通讯作者：
Ananaba, Godwin A.
影响因子：
2.8
作者：
Delimaris, Loannis;Faviou, Elsa;Dionyssiou-Asteriou, Amalia
通讯作者：
Dionyssiou-Asteriou, Amalia
影响因子：
3.8
作者：
Bahl, M;Ennis, M;Goodwin, PJ
通讯作者：
Goodwin, PJ