Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations.
Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations.
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发表时间：
1994-01
期刊：
影响因子：
11.2
通讯作者：
M. Caligiuri;S. Schichman;Matthew P. Strout;K. Mrózek;Maria R. Baer;Stanley R. Frankel;Maurice Barcos;Geoffrey P. Herzig;Cario M. Croce;C. Bloomfield
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作者：
M. Caligiuri;S. Schichman;Matthew P. Strout;K. Mrózek;Maria R. Baer;Stanley R. Frankel;Maurice Barcos;Geoffrey P. Herzig;Cario M. Croce;C. Bloomfield
涉及染色体带11 q23的易位常见于患有急性髓性白血病（AML）或急性淋巴细胞白血病的婴儿和成人。我们先前克隆了一个名为ALL-1的基因，该基因跨越11 q23断点，在大多数11 q23异常的白血病病例中重排。在本报告中，我们调查了ALL-1重排的发生在AML的情况下，没有11 q23异常的细胞遗传学证据。我们在4例初发AML和11三体作为唯一染色体异常的患者中的3例中检测到ALL-1基因的分子重排。此外，我们在19例细胞遗传学正常的初发AML患者中发现2例ALL-1基因重排。我们的结论是，ALL-1的分子重排往往可以在初发AML中检测到，尽管没有涉及11 q23的细胞遗传学异常。
Translocations which involve chromosome band 11q23 are frequently found in infants and adults with acute myeloid leukemia (AML) or acute lymphoblastic leukemia. We previously cloned a gene called ALL-1 which spans the 11q23 breakpoint and is rearranged in most cases of leukemia with 11q23 abnormalities. In the present report, we have investigated the occurrence of ALL-1 rearrangement in cases of AML without cytogenetic evidence of 11q23 abnormalities. We detected molecular rearrangements of the ALL-1 gene in 3 of 4 patients with de novo AML and trisomy 11 as a sole chromosomal abnormality. Furthermore, we found DNA rearrangements of ALL-1 in 2 of 19 patients with de novo AML and normal cytogenetics. We conclude that molecular rearrangement of ALL-1 often can be detected in de novo AML, despite the absence of cytogenetic abnormalities involving 11q23.