A general dual-bolus approach for quantitative DCE-MRI
A general dual-bolus approach for quantitative DCE-MRI
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DOI：
10.1016/j.mri.2010.08.009
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发表时间：
2011-02-01
影响因子：
2.5
通讯作者：
Cheng, Hai-Ling Margaret
中科院分区：
文献类型：
--
作者：
Kershaw, Lucy E.;Cheng, Hai-Ling Margaret
目的：为了提出一种双团注技术定量动态对比增强MRI（DCE-MRI），并表明它可以给动脉输入功能（AIF）测量相当于从一个单一的团注protocol.Methods：5只兔子成像使用双团注技术适用于高分辨率DCE-MRI，结合时间分辨成像的对比动力学（TRICKS）序列的快速时间采样。从腹主动脉中的低剂量预团注和高剂量主团注测量AIF。在一只动物中，TRICKS和快速破坏梯度回波（FSPGR）收购compared.Results：缩放prebolus AIF显示匹配的主要团AIF，与95%的置信区间重叠的伽玛变量函数的第一次通过和线性拟合的洗脱阶段，与例外的一种情况。使用TRICKS和FSPGR测量的AIF被证明是在一个animal.Conclusion：所提出的技术可以捕获，甚至在兔主动脉的快速循环动力学，和缩放prebolus AIF是相当于从高剂量注射的AIF。这允许单独测量AIF和组织摄取曲线，这意味着可以使用针对其特定要求定制的协议来获取每条曲线。(C)2011 Elsevier Inc. All rights reserved.
Purpose: To present a dual-bolus technique for quantitative dynamic contrast-enhanced MRI (DCE-MRI) and show that it can give an arterial input function (AIF) measurement equivalent to that from a single-bolus protocol.Methods: Five rabbits were imaged using a dual-bolus technique applicable for high-resolution DCE-MRI, incorporating a time resolved imaging of contrast kinetics (TRICKS) sequence for rapid temporal sampling. AIFs were measured from both the low-dose prebolus and the high-dose main bolus in the abdominal aorta. In one animal, TRICKS and fast spoiled gradient echo (FSPGR) acquisitions were compared.Results: The scaled prebolus AIF was shown to match the main bolus AIF, with 95% confidence intervals overlapping for fits of gamma-variate functions to the first pass and linear fits to the washout phase, with the exception of one case. The AIFs measured using TRICKS and FSPGR were shown to be equivalent in one animal.Conclusion: The proposed technique can capture even the rapid circulation kinetics in the rabbit aorta, and the scaled prebolus AIF is equivalent to the AIF from a high-dose injection. This allows separate measurements of the AIF and tissue uptake curves, meaning that each curve can then be acquired using a protocol tailored to its specific requirements. (C) 2011 Elsevier Inc. All rights reserved.