Engineering the Lymphatic System.
Engineering the Lymphatic System.
复制标题
工程淋巴系统。
DOI：
10.1007/s13239-011-0054-6
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发表时间：
2011
影响因子：
1.8
通讯作者：
Dixon,JBrandon
中科院分区：
文献类型：
--
作者：
Nipper,MatthewE;Dixon,JBrandon
我们对淋巴生理学的理解以及淋巴系统在积极调节体液平衡、脂质转运和免疫细胞运输中的作用的最新进展，部分通过成像、组织工程、定量生物学、生物力学和计算建模方面的创新得到了进一步发展。跨学科和生物工程方法将继续对该领域的发展至关重要，因为淋巴生物学和功能与血管所经历的局部微环境和机械负荷密切相关。这在淋巴疾病如水肿中尤其如此，其中微环境可以通过组织纤维化和脂肪细胞积累而急剧改变。在这次审查中，我们将突出的贡献，工程和力学淋巴生理学，并将讨论领域，将是重要的未来研究。
The recent advances in our understanding of lymphatic physiology and the role of the lymphatics in actively regulating fluid balance, lipid transport, and immune cell trafficking has been furthered in part through innovations in imaging, tissue engineering, quantitative biology, biomechanics, and computational modeling. Interdisciplinary and bioengineering approaches will continue to be crucial to the progression of the field, given that lymphatic biology and function are intimately woven with the local microenvironment and mechanical loads experienced by the vessel. This is particularly the case in lymphatic diseases such as lymphedema where the microenvironment can be drastically altered by tissue fibrosis and adipocyte accumulation. In this review we will highlight contributions that both engineering and mechanics have made to lymphatic physiology and will discuss areas that will be important for future research.