Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway
Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway
复制标题
玉米须粗多糖通过阻断EGFR/PI3K/AKT/CREB信号通路发挥抗胰腺癌活性
DOI：
10.1039/d0fo00403k
复制
发表时间：
2020-08-01
期刊：
影响因子：
6.1
通讯作者：
Ding, Kan
中科院分区：
文献类型：
--
作者：
Tao, Hong;Chen, Xia;Ding, Kan
胰腺癌是一种高致死性的恶性实体瘤。胰腺癌的治疗受到严重限制，因为它具有高度的耐药性和免疫抑制性。因此，迫切需要探索新的抗胰腺癌治疗方法。在这项研究中，我们表明，S1，一种来自玉米须的粗多糖，可以显着抑制胰腺癌细胞在体外和体内的增殖。进一步的研究表明，S1可以诱导胰腺癌细胞凋亡，将细胞周期阻滞在S期，并阻止胰腺癌细胞的迁移和侵袭。S1可能通过阻断EGFR/PI 3 K/AKT/CREB信号通路发挥抗胰腺癌活性。而S1在体内外几乎无毒性。这些结果提供了证据，表明S1是一种新的功能性食品成分，可以开发用于对抗胰腺癌。
Pancreatic cancer is a highly lethal and malignant solid tumor. Treatments for pancreatic cancer are seriously limited because it is highly drug-resistant and immunosuppressive. Hence, it is urgent to explore novel approaches for anti-pancreatic cancer therapy. In this study, we show that S1, a crude polysaccharide from corn silk, may significantly inhibit pancreatic cancer cell proliferationin vitroandin vivo. Further studies reveal that S1 can induce pancreatic cancer cell apoptosis, arrest the cell cycle in S phase and impede pancreatic cancer cell migration and invasion. Moreover, S1 may block the EGFR/PI3K/AKT/CREB signaling pathway to exert its anti-pancreatic cancer activity. However, S1 has almost no toxicity eitherin vitroorin vivo. These results provide evidence that S1 is a new functional food component that can be developed to fight pancreatic cancer.