HISTOLOGY OF WOUND, VITREOUS, AND RETINA IN EXPERIMENTAL POSTERIOR PENETRATING EYE INJURY IN THE RHESUS-MONKEY
HISTOLOGY OF WOUND, VITREOUS, AND RETINA IN EXPERIMENTAL POSTERIOR PENETRATING EYE INJURY IN THE RHESUS-MONKEY
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DOI：
10.1016/0002-9394(79)90469-0
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发表时间：
1979-01-01
影响因子：
4.2
通讯作者：
RYAN, SJ
中科院分区：
文献类型：
--
作者：
CLEARY, PE;RYAN, SJ
进行组织学研究以支持对恒河猴眼穿透伤后牵拉性视网膜脱离机制的临床观察。猴眼（40只眼; 40只猴）的特征为眼内纤维化，形成环状膜以及视网膜前膜和视网膜下膜。仅在玻璃体中有血液的眼睛中发生伤口纤维向内生长的进展。玻璃体内成纤维细胞增生主要来源于睫状体和脉络膜的基质，但也可能来自非色素睫状体上皮。玻璃体内的成纤维细胞的反应是目前早在4天后受伤，并已进展到6周形成一个环状膜。视网膜前膜被确定为早在4周后损伤。它们在赤道前的周边视网膜上最突出。它们很可能来源于多种细胞来源，包括来自伤口的纤维向内生长，但它们也通过组织桥连接到视网膜表面，表明神经胶质来源。视网膜下膜似乎来源于视网膜色素上皮细胞和神经胶质细胞。
A histologic study was performed to support clinical observations on the mechanisms responsible for traction retinal detachment after a penetrating injury in the rhesus monkey eye. The monkey eyes (40 eyes; 40 monkeys) were characterized by intraocular fibrosis with the formation of a cyclitic membrane and epiretinal and subretinal membranes. The progression to a fibrous ingrowth from the wound occurred only in eyes with blood in the vitreous. The intravitreal fibroblastic proliferation had its origin mainly from the stroma of the ciliary body and choroid at the wound but probably also from the nonpigmented ciliary epithelium. A fibroblastic response was present within the vitreous as early as 4 days after injury, and had progressed to form a cyclitic membrane by 6 wk. Epiretinal membranes were identified as early as 4 wk after injury. They were most prominent over the peripheral retina anterior to the equator. It is likely that they are derived from multiple cellular sources including the fibrous ingrowth from the wound but they were also connected to the surface of the retina by bridges of tissue indicating a glial origin. The subretinal membranes appeared to be derived from both retinal pigment epithelium cells and glial cells.