Correlation between HIV viral load and aminotransferases as liver damage markers in HIV infected naive patients: a concordance cross-sectional study.
Correlation between HIV viral load and aminotransferases as liver damage markers in HIV infected naive patients: a concordance cross-sectional study.
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DOI：
10.1186/1743-422x-6-181
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发表时间：
2009-10-30
期刊：
影响因子：
4.8
通讯作者：
Alfaro-Mejía A
中科院分区：
文献类型：
--
作者：
Mata-Marín JA;Gaytán-Martínez J;Grados-Chavarría BH;Fuentes-Allen JL;Arroyo-Anduiza CI;Alfaro-Mejía A
肝功能检查的异常可能完全是由人类免疫缺陷病毒（HIV）引起的肝细胞直接炎症引起的。 HIV引起肝损伤的机制仍不清楚。我们的目的是确定 HIV 病毒载量与血清天冬氨酸转氨酶 (AST) 和丙氨酸转氨酶 (ALT) 水平之间的相关性，作为 HIV 初次感染患者肝损伤的标志物。我们进行了一项一致性横断面研究。有抗病毒治疗经历、使用肝毒性药物或合并感染的患者被排除。我们使用皮尔逊相关系数来计算血清转氨酶水平与 HIV 病毒载量之间的相关性。我们招募了 2006 年至 2008 年就诊的 59 名患者，其中 50 名男性和 9 名女性。受试者的平均 (± SD) 年龄为 34.24 ± 9.5，AST 37.73 ± 29.94 IU/mL，ALT 43.34 ± 42.41 IU/mL，HIV 病毒载量 199,243 ± 292,905 拷贝/mL， CD4+ 细胞计数 361 ± 289 个细胞/mm3。 AST 血清水平与 HIV 病毒载量之间存在中等强度的正相关性（r = 0.439，P < 0.001）； ALT 血清水平与 HIV 病毒载量之间存在弱相关性（r = 0.276，P = 0.034）；调整线性回归模型中的混杂因素后，相关性仍然显着。我们的研究结果表明，HIV 病毒载量与转氨酶作为肝损伤标志物之间存在关联。我们应该提高对艾滋病病毒感染者肝损伤的认识、诊断和潜在治疗。
Abnormalities in liver function tests could be produced exclusively by direct inflammation in hepatocytes, caused by the human immunodeficiency virus (HIV). Mechanisms by which HIV causes hepatic damage are still unknown. Our aim was to determine the correlation between HIV viral load, and serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as markers of hepatic damage in HIV naive infected patients. We performed a concordance cross-sectional study. Patients with antiviral treatment experience, hepatotoxic drugs use or co-infection were excluded. We used a Pearson's correlation coefficient to calculate the correlation between aminotransferases serum levels with HIV viral load. We enrolled 59 patients, 50 men and 9 women seen from 2006 to 2008. The mean (± SD) age of our subjects was 34.24 ± 9.5, AST 37.73 ± 29.94 IU/mL, ALT 43.34 ± 42.41 IU/mL, HIV viral load 199,243 ± 292,905 copies/mL, and CD4+ cells count 361 ± 289 cells/mm3. There was a moderately strong, positive correlation between AST serum levels and HIV viral load (r = 0.439, P < 0.001); and a weak correlation between ALT serum levels and HIV viral load (r = 0.276, P = 0.034); after adjusting the confounders in lineal regression model the correlation remained significant. Our results suggest that there is an association between HIV viral load and aminotransferases as markers of hepatic damage; we should improved recognition, diagnosis and potential therapy of hepatic damage in HIV infected patients.