Potential Biomarkers of Preeclampsia: Inverse Correlation between Hydrogen Peroxide and Nitric Oxide Early in Maternal Circulation and at Term in Placenta of Women with Preeclampsia
Potential Biomarkers of Preeclampsia: Inverse Correlation between Hydrogen Peroxide and Nitric Oxide Early in Maternal Circulation and at Term in Placenta of Women with Preeclampsia
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DOI：
10.1016/j.placenta.2009.01.003
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发表时间：
2009-04-01
期刊：
影响因子：
3.8
通讯作者：
Leblanc, S.
中科院分区：
文献类型：
--
作者：
Aris, A.;Benali, S.;Leblanc, S.
先兆子痫（PE）是一种妊娠特异性疾病，与母亲及其子女未来的心血管疾病有关。PE的病因尚不清楚，但氧化应激似乎在PE中显示的内皮功能障碍和永久性全身血管收缩中起主要作用。过氧化氢（H2 O2），细胞氧化应激级联反应的终末代谢产物，也被发现是胎盘氧化缺血/再灌注应激的一个组成部分。我们是第一个显示H2 O2水平的增加，在血清中的先兆子痫的妇女在任期。已知H2 O2通过增加脱氢酶的代谢来减少NO的产生。本研究的目的是调查一氧化氮（NO），一种有效的血管扩张剂，和H2 O2在整个怀孕期间可能存在的相关性。因此，我们同时评估了正常和先兆子痫妇女在怀孕10-15周和37-40周的血清中NO和H2 O2的水平，以及分娩时胎盘中的NO和H2 O2的水平。我们的研究结果表明，H2 O2水平升高和NO水平降低之间呈负相关，在母体循环早期和在足月胎盘。我们的体外实验证实了这种关系，表明H2 O2抑制细胞滋养层细胞的NO合成。总之，我们的研究结果突出了H2 O2和NO之间的负相关性早期在母体循环和胎盘的妇女先兆子痫，铺平了道路，进一步研究的潜在用途NO和H2 O2作为生物标志物在先兆子痫的预测。(C)2009爱思唯尔有限公司保留所有权利。
Preeclampsia (PE) is a pregnancy-specific disease that has been associated with future cardiovascular disease for the mother and her child. The etiology of PE is unclear but oxidative stress seems to play a major role in endothelial dysfunction and permanent systemic vasoconstriction shown in PE. Hydrogen peroxide (H2O2), a terminal metabolite of the cellular oxidative stress cascade, is also revealed as a component of oxidative ischemia/reperfusion stress in placenta. We were the first to show an increase in the levels of H2O2 in the serum of preeclamptic women at term. H2O2 is already known to reduce the production of NO by increasing the metabolism of arginases. The objective of this study was to investigate a possible correlation between nitric oxide (NO), a potent vasodilator, and H2O2 throughout pregnancy. Thus, we simultaneously assessed the levels of No and H2O2 in the serum of normal and preeclamptic women at 10-15 and 37-40 weeks of pregnancy, and in placentas at delivery. Our findings showed an inverse correlation between increased levels of H2O2 and decreased levels of NO early in maternal circulation and at term in placenta. This relationship is confirmed by our in vitro experiments which demonstrate that H2O2 inhibits NO synthesis of cytotrophoblasts. In conclusion, our findings highlight an inverse correlation between H2O2 and NO early in maternal circulation and in placenta of women with preeclampsia, paving the way for further studies examining the potential use of NO and H2O2 as biomarkers in the prediction of preeclampsia. (C) 2009 Elsevier Ltd. All rights reserved.