Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors
Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors
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DOI：
10.1103/physrevx.12.031006
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发表时间：
2022-07-11
影响因子：
12.5
通讯作者：
Dogic, Zvonimir
中科院分区：
文献类型：
--
作者：
Lemma, Bezia;Mitchell, Noah P.;Dogic, Zvonimir
细丝和分子马达的混合物形成了具有不同动力学行为的活性材料，这些动力学行为基于其成分而变化？分子性质为了开发这些材料的多尺度，我们绘制了微管和尖端积累驱动蛋白-4分子马达的非平衡相图。我们发现，驱动蛋白-4可以驱动全球收缩或顺从性的伸展动力学，这取决于微管和捆绑剂的浓度。我们还观察到一系列的空间异质非平衡相，包括有限大小的径向星，一维蠕虫状链，扩展的二维双层，和系统跨越三维活性泡沫。最后，我们描述了复杂的动力学途径，产生微相分离的结构和产生的固有挫折之间的取向顺序的丝状微管和尖端积累分子马达的位置顺序。我们的工作揭示了一系列新颖的活性态。它还表明，主动应力的形式不仅取决于单个马达和细丝的性质，而且还取决于细丝上马达的成分浓度和空间布置。
Mixtures of filaments and molecular motors form active materials with diverse dynamical behaviors that vary based on their constituents??? molecular properties. To develop a multiscale of these materials, we map the nonequilibrium phase diagram of microtubules and tip-accumulating kinesin-4 molecular motors. We find that kinesin-4 can drive either global contractions or turbulentlike extensile dynamics, depending on the concentrations of both microtubules and a bundling agent. We also observe a range of spatially heterogeneous nonequilibrium phases, including finite-sized radial asters, 1D wormlike chains, extended 2D bilayers, and system-spanning 3D active foams. Finally, we describe intricate kinetic pathways that yield microphase separated structures and arise from the inherent frustration between the orientational order of filamentous microtubules and the positional order of tip-accumulating molecular motors. Our work reveals a range of novel active states. It also shows that the form of active stresses is not solely dictated by the properties of individual motors and filaments, but is also contingent on the constituent concentrations and spatial arrangement of motors on the filaments.