The origin and application of experimental autoimmune encephalomyelitis
The origin and application of experimental autoimmune encephalomyelitis
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DOI：
10.1038/nri2190
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发表时间：
2007-11-01
影响因子：
100.3
通讯作者：
Baxter, Alan G.
中科院分区：
文献类型：
--
作者：
Baxter, Alan G.
实验性自身免疫性脑脊髓炎（EAE）是一种神经免疫系统对中枢神经系统（CNS）限制性抗原引发反应的模型。它是疫苗接种后脑炎的极好模型和多发性硬化症的许多方面的有用模型。EAE已在许多物种中建立，并通过用大量CNS衍生抗原引发而诱导。因此，发病机制、病理学和临床体征在实验方案之间显著不同。正如我在这篇时间轴文章中所描述的，在EAE的某些研究中采取的还原论方法导致了对在狭窄范围的条件下获得的结果的依赖。虽然这些研究对我们对炎症、T细胞活化和MHC限制的分子理解做出了重要贡献，但它们并没有有效地促进我们对通常发生在CNS免疫病理学和自身免疫中的多抗原反应的认识。
Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. it is an excellent model of post-vaccinal encephalitis and a useful model of many aspects of multiple sclerosis. EAE has been established in numerous species and is induced by priming with a large number of CNS-derived antigens. As a consequence, the pathogenesis, pathology and clinical signs vary significantly between experimental protocols. As I describe in this Timeline article, the reductionist approach taken in some lines of investigation of EAE resulted in a reliance on results obtained under a narrow range of conditions. Although such studies made important contributions to our molecular understanding of inflammation, T-cell activation, and MHC restriction, they did not advance as effectively our knowledge of the polyantigenic responses that usually occur in CNS immunopathology and autoimmunity.