Effects of a single bout of high-intensity interval exercise on C1q/TNF-related proteins
Effects of a single bout of high-intensity interval exercise on C1q/TNF-related proteins
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DOI：
10.1139/apnm-2018-0355
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发表时间：
2019-01-01
影响因子：
3.4
通讯作者：
Nakagaki, Kohei
中科院分区：
文献类型：
--
作者：
Kon, Michihiro;Ebi, Yoshiko;Nakagaki, Kohei
高强度间歇训练（HUT）被认为是改善能量底物代谢和胰岛素敏感性的有效运动训练方案。然而，HUT 改善胰岛素敏感性的潜在机制尚未完全阐明。 C1q/肿瘤坏死因子相关蛋白 (CTRP) 1 和 CTRP9 是脂联素旁系同源物和新型脂肪因子，对能量底物代谢和胰岛素敏感性具有良好的影响。本研究的目的是调查单次 HIIT 对健康男性 CTRP1 和 CTRP9 分泌的影响。八名健康男性受试者（平均+/- SE：年龄，23.4 +/- 1.1 岁；身高，172.1 +/- 1.7 cm；体重，68.0 +/- 2.0 kg；体重指数，22.9 +/- 0.5 kg/m(2)）参与了这项研究。他们使用自行车测力计进行了单次 HIIT 训练，其中包括四次 30 秒的最大自行车训练，两次训练之间休息 4 分钟。在运动前、单次 HIIT 后 0 分钟（运动后立即）、15、30 和 120 分钟采集血样。使用酶联免疫溶剂测定试剂盒测量血清 CTRP1、CTRP9 和高分子量 (HMW) 脂联素浓度。 CTRP1 浓度在 HIIT 后 120 分钟显着增加。单次 HIIT 后 CTRP9 浓度也立即显着增加。相比之下，急性HIIT前后HMW脂联素浓度没有显着差异。这些发现表明，单次 HIIT 可能会刺激健康男性 CTRP1 和 CTRP9 的分泌。
High-intensity interval training (HUT) is known to be an effective exercise training regimen to improve energy substrate metabolism and insulin sensitivity. However, the underlying mechanisms of improvement in insulin sensitivity due to HUT have not yet been fully clarified. C1q/tumor necrosis factor-related protein (CTRP) 1 and CTRP9, which are adiponectin paralogs and novel adipokines, have favorable effects on energy substrate metabolism and insulin sensitivity. The purpose of this study was to investigate the effects of a single bout of HIIT on CTRP1 and CTRP9 secretions in healthy men. Eight healthy male subjects (mean +/- SE: age, 23.4 +/- 1.1 years; height, 172.1 +/- 1.7 cm; body mass, 68.0 +/- 2.0 kg; body mass index, 22.9 +/- 0.5 kg/m(2)) participated in this study. They performed a single bout of HIIT consisted of four 30-s maximal cycling bouts with 4 min of rest between bouts using a cycle ergometer. Blood samples were collected before the exercise, at 0 (immediately after the exercise), 15, 30, and 120 min after the single bout of HIIT. Serum CTRP1, CTRP9, and high-molecular-weight (HMW) adiponectin concentrations were measured using enzyme-linked immunosolvent assay kits. CTRP1 concentration significantly increased at 120 min after the HIIT. CTRP9 concentration also significantly increased immediately after the single bout of HIIT. In contrast, there were no significant differences in HMW adiponectin concentration before and after the acute HIIT. These findings suggest that a single bout of HIIT may stimulate CTRP1 and CTRP9 secretions in healthy men.