Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging
Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging
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DOI：
10.1002/nbm.1479
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发表时间：
2010-06-01
影响因子：
2.9
通讯作者：
Ohtomo, Kuni
中科院分区：
文献类型：
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作者：
Abe, Osamu;Yamasue, Hidenori;Ohtomo, Kuni
本研究的目的是阐明性别差异的全球和区域的灰色/白色物质的体积，平均扩散率（MD），和分数各向异性（FA）在正常老化过程中使用基于体素的分析。我们研究了245名健康的右利手受试者，年龄范围很广（115名女性，22-70岁; 130名男性，21-71岁）。关于整体效应，纳入二次年龄项改善了白色物质分数和MD数据的拟合，但对整体灰质体积/分数或FA没有改善。关于区域效应，我们发现前优势体积损失，FA减少主要是在前白色物质，和MD增加主要是在侧裂周区域和脑室周围白色物质对年龄的两种性别。与女性相比，我们发现男性右下额颞区的FA下降幅度更大，延伸到前扣带皮层，男性双侧额叶、颞叶和顶叶区的MD加速增加。没有区域的性别与年龄的相互作用是显着的区域体积，或在其中一个陡峭的FA下降或加速MD增加的妇女是显着的。我们的研究结果提供了强有力的证据，性别二型性的全球和局灶性扩散的特点，在正常老化。版权所有（C）2010约翰威利父子有限公司
The purpose of this study is to elucidate sex differences in global and regional gray/white matter volume, mean diffusivity (MD), and fractional anisotropy (FA) during normal aging using voxel-based analysis. We studied 245 healthy right-handed subjects with a wide range of ages (115 women, 22-70 years; 130 men, 21-71 years). Regarding global effects, inclusion of a quadratic age term improved the fit to data for white matter fraction and MD, but not for global gray matter volume/fraction or FA. Regarding regional effects, we found anterior-dominant volume loss, FA decrease predominantly in the anterior white matter, and MD increase predominantly in perisylvian regions and periventricular white matter against age for both sexes. Compared with women, we found a steeper FA decline for men in the right inferior fronto-temporal areas, extending to the anterior cingulate cortex, and an accelerated MD increase for men in the bilateral frontal, temporal, and parietal areas. There was no area in which interaction of sex with age was significant for regional volume, or in which a steeper FA decline or accelerated MD increase for women was significant. Our results provide strong evidence of sex dimorphism in global and focal diffusion characteristics during normal aging. Copyright (C) 2010 John Wiley & Sons, Ltd.