Immunological implications of pregnancy-induced microchimerism.
Immunological implications of pregnancy-induced microchimerism.
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DOI：
10.1038/nri.2017.38
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Way SS
中科院分区：
文献类型：
--
作者：
Kinder JM;Stelzer IA;Arck PC;Way SS
传统上，免疫学身份是由遗传编码的抗原定义的，由于孟德尔式的遗传，母亲和父亲的贡献是平等的。然而，垂直转移的母体细胞在整个出生后发育过程中也以非常低的水平存在于个体中。反过来，母亲在怀孕期间被植入具有异种基因的胎儿细胞，这些细胞在分娩后很长一段时间内仍然存在。最近的发现表明，这些表达非遗传的与家庭相关的抗原特征的微嵌合细胞并不是意外的怀孕纪念品，而是故意保留在母亲及其后代体内，通过改善未来怀孕的结果来促进遗传适应性。在这里，我们讨论的免疫学含义，好处和潜在的后果，个人是构成嵌合体的生物活性的‘微芯片’的遗传外来细胞。
Immunological identity is traditionally defined by genetically encoded antigens, with equal maternal and paternal contributions as a result of Mendelian inheritance. However, vertically transferred maternal cells also persist in individuals at very low levels throughout postnatal development. Reciprocally, mothers are seeded during pregnancy with genetically foreign fetal cells that persist long after parturition. Recent findings suggest that these microchimeric cells expressing noninherited familially relevant antigenic traits are not accidental souvenirs of pregnancy, but are purposefully retained within mothers and their offspring to promote genetic fitness by improving the outcome of future pregnancies. Here, we discuss the immunological implications, benefits and potential consequences of individuals being constitutively chimeric with a biologically active ‘microchiome’ of genetically foreign cells.
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DOI：
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发表时间：
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