Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.
Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.
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DOI：
10.3390/molecules27134297
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发表时间：
2022-07-04
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影响因子：
--
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单胺氧化酶抑制剂（MAOIs）是治疗抑郁症和其他神经系统疾病的一类重要药物。有证据表明，非典型抑郁症患者优先对天然产物MAOIs有反应。这篇综述介绍了天然产物的全面调查，主要来自植物来源，作为潜在的新的MAOI药物先导。一些传统使用的植物和草药配方的精神活性特性归因于它们的MAOI成分。MAO抑制成分也可能对天然产物的神经保护作用负责。从天然产物中鉴定出不同种类的MAO-A和-B具有非选择性和选择性抑制作用。选择性可逆的天然产物MAOIs可能是传统MAOIs药物更安全的替代品。表征传统上用作精神活性制剂或用于治疗神经系统疾病的天然产物的MAO抑制成分可能有助于理解作用机制，优化这些制剂以获得所需的生物活性特性，并提高治疗潜力。本文还讨论了天然产物MAOIs在神经母细胞瘤治疗中的潜在应用。
Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs. This review presents a comprehensive survey of the natural products, predominantly from plant sources, as potential new MAOI drug leads. The psychoactive properties of several traditionally used plants and herbal formulations were attributed to their MAOI constituents. MAO inhibitory constituents may also be responsible for neuroprotective effects of natural products. Different classes of MAOIs were identified from the natural product sources with non-selective as well as selective inhibition of MAO-A and -B. Selective reversible natural product MAOIs may be safer alternatives to the conventional MAOI drugs. Characterization of MAO inhibitory constituents of natural products traditionally used as psychoactive preparations or for treatment of neurological disorders may help in understanding the mechanism of action, optimization of these preparations for desired bioactive properties, and improvement of the therapeutic potential. Potential therapeutic application of natural product MAOIs for treatment of neuroblastoma is also discussed.
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影响因子：
6.1
作者：
Carradori, Simone;Gidaro, Maria Concetta;Petzer, Jacobus P.
通讯作者：
Petzer, Jacobus P.
DOI：
10.3390/molecules26196019
发表时间：
2021-10-04
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Aljanabi R;Alsous L;Sabbah DA;Gul HI;Gul M;Bardaweel SK
通讯作者：
Bardaweel SK
DOI：
10.1155/2017/4018724
发表时间：
2017
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chaurasiya ND;León F;Ding Y;Gómez-Betancur I;Benjumea D;Walker LA;Cutler SJ;Tekwani BL
通讯作者：
Tekwani BL
影响因子：
2.7
作者：
Baek, Seung Cheol;Lee, Hyun Woo;Kim, Hoon
通讯作者：
Kim, Hoon
影响因子：
2.7
作者：
Baek, Seung Cheol;Kang, Myung-Gyun;Kim, Hoon
通讯作者：
Kim, Hoon