CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene
CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene
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DOI：
10.1046/j.1365-2249.2000.01292.x
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发表时间：
2000-08-01
影响因子：
4.6
通讯作者：
Werdelin, O
中科院分区：
文献类型：
--
作者：
Boesen, M;Svane, IM;Werdelin, O
试图确定CD 8（+）T细胞对生长中的肿瘤施加的选择压力。为此，在T细胞缺陷的裸鼠和同源T细胞感受态nu/+小鼠中用3-甲基胆蒽诱导的肿瘤被移植到nu/+受体。裸鼠肉瘤的排斥率几乎是nu/+小鼠肉瘤的两倍。在移植前nu/+受体的CD 8（+）T细胞的消耗使他们接受裸肿瘤，而未经治疗的nu/+受体一直排斥裸肿瘤。这些发现表明，甲基胆蒽肉瘤在T细胞活性宿主中生长期间，通过选择性消除对CD 8（+）T细胞介导的裂解敏感的高免疫原性肿瘤细胞来适应T细胞系统。
An attempt was made to identify the selection pressures put upon a growing tumour by CD8(+) T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was almost twice that of the sarcomas from nu/+ mice. Depletion of CD8(+) T cells from nu/+ recipients prior to transplantation made them accept nude tumours that were consistently rejected by untreated nu/+ recipients. These findings suggest that a methylcholanthrene sarcoma during its growth in a T cell-competent host adapts to the T cell system through a selective elimination of highly immunogenic tumour cells that are susceptible to CD8(+) T cell-mediated lysis.