Splanchnic ischaemia and multiple organ failure
Splanchnic ischaemia and multiple organ failure
复制标题
内脏缺血和多器官衰竭
作者：
M. Keighley
5-氨基水杨酸盐的酸度降低，表明5-氨基水杨酸盐与次氯酸盐之间发生化学反应。活化的中性粒细胞也产生过氧化物酶产生的氧代谢产物，其与5-氨基水杨酸反应产生非荧光产物。6因此，我们建议5-氨基水杨酸作为次氯酸盐清除剂，也作为次氯酸盐指示剂。因此，在接受5-氨基水杨酸盐的患者的粪便流中鉴定和检测5-氨基水杨酸盐的中性粒细胞衍生的代谢物将为发炎的肠中次氯酸盐的产生提供证据，并且还可用于监测疾病的进展。
cence of 5-aminosalicylate decreased, suggesting a chemical reaction between 5-aminosalicylate and hypochlorite. Activated neutrophils also produced a peroxidasegenerated oxygen metabolite which reacted with 5-aminosalicylate to produce a nonfluorescent product.6 We therefore propose that 5-aminosalicylate acts as a hypochlorite scavenger and also as a hypochlorite indicator. Identification and detection of neutrophil derived metabolites of 5-aminosalicylate in the faecal stream of patients receiving 5-aminosalicylate would thus provide evidence for the production of hypochlorite in the inflamed bowel and may also be useful for monitoring the progress of the disease.