Ni-catalyzed reductive addition of alkyl halides to isocyanides.
Ni-catalyzed reductive addition of alkyl halides to isocyanides.
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DOI：
10.1039/c5ob01901j
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发表时间：
2015-11
影响因子：
3.2
通讯作者：
Bo Wang;Yijing Dai;W. Tong;H. Gong
中科院分区：
文献类型：
--
作者：
Bo Wang;Yijing Dai;W. Tong;H. Gong
本文重点介绍了使用锌作为末端还原剂，用富电子和缺电子芳基异氰化物在镍催化下还原捕获仲烷基和叔烷基自由基，以良好的收率得到 6-烷基化菲啶。卡宾配体的使用需要烷基自由基过程，并且代表了在镍催化还原条件下从卤化物前体生成未活化的烷基自由基的首次应用。
This paper highlights Ni-catalyzed reductive trapping of secondary and tertiary alkyl radicals with both electron-rich and electron-deficient aryl isocyanides using zinc as the terminal reductant, affording 6-alkylated phenanthridine in good yields. The employment of carbene ligands necessitates the alkyl radical process, and represents the first utility in the Ni-catalyzed reductive conditions for the generation of unactivated alkyl radicals from the halide precursors.