Hostility, Risk of Coronary Heart Disease, and Mortality
Hostility, Risk of Coronary Heart Disease, and Mortality
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敌意、冠心病风险和死亡率
DOI：
10.1097/00006842-198305000-00003
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发表时间：
1983
影响因子：
3.3
通讯作者：
O. Paul
中科院分区：
文献类型：
--
作者：
R. Shekelle;M. Gale;A. Ostfeld;O. Paul
&NA;在对1877名无冠心病（CHD）的中年男性进行初步检查时，通过明尼苏达多相人格量表的50项子量表评估敌意水平（Ho）。10年主要CHD事件（心肌梗死和CHD死亡）的发生率在Ho量表分布的第一个五分位数中最低，在中间五分位数中最高，在其他三个五分位数中居中。校正年龄、血压、血清胆固醇水平、吸烟和乙醇摄入后，Ho评分小于或等于10分的男性与Ho评分较高的男性相比，发生主要CHD事件的相对几率为0.68。Ho量表与CHD、恶性肿瘤以及心血管-肾脏疾病和恶性肿瘤以外的原因的20年粗死亡率呈正相关。调整上述风险因素后，Ho量表与20年全因死亡风险总和呈统计学显著、正、单调相关。在Ho量表上相差23分，即，第一和第五个五分位数的平均值之间的差异与死亡风险增加42%有关。这些结果支持了威廉姆斯等人先前关于Ho量表和冠状动脉粥样硬化的发现，并且还表明Ho量表可能与对生存具有广泛影响的因素相关。
&NA; Level of hostility (Ho) was assessed by a 50‐item subscale of the Minnesota Multiphasic Personality Inventory at the initial examination of 1877 employed middle‐aged men who were free of coronary heart disease (CHD). Ten‐year incidence of major CHD events (myocardial infarction and CHD death) was lowest in the first quintile of the Ho scale's distribution, highest in the middle quintile, and intermediate in the other three quintiles. After adjustment for age, blood pressure, serum cholesterol level, cigarette smoking, and intake of ethanol, the relative odds of a major CHD event was 0.68 for men with Ho scores less than or equal to 10 points in comparison to men with higher scores. The Ho scale was positively associated with crude 20‐year mortality from CHD, malignant neoplasms, and causes other than cardiovascular—renal diseases and malignant neoplasms. After adjustment for the risk factors listed above, the Ho scale had a statistically significant, positive, monotonic association with 20‐year risk of death from all causes combined. A difference of 23 points on the Ho scale, i.e., the difference between the means of the first and the fifth quintiles, was associated with a 42% increase in the risk of death. These results support the previous findings of Williams et al. with respect to the Ho scale and coronary atherosclerosis, and also suggest that the Ho scale may be associated with factors having broad effects on survival.