Immunosuppression by mouse sialylated α-foetoprotein
Immunosuppression by mouse sialylated α-foetoprotein
复制标题
小鼠唾液酸化甲胎蛋白的免疫抑制
作者：
E. F. Zimmerman;M. Voorting;J. G. Michael
AFP 是早期胚胎生命中的主要血清蛋白。它也被认为是一种肿瘤相关抗原，因为它出现在原发性肝癌患者和动物的血清中1。 AFP 在胎儿中的功能仍不清楚。 Tomasi等人2证明小鼠AFP在体内和体外对抗体合成具有免疫抑制作用。同样，据报道，人类 AFP 具有免疫抑制特性3。我们中的一个人 (E.F.Z.) 发现小鼠 AFP 是异质的，由五种成分 (Fp1-Fp5)4 组成，其附着在分子上的唾液酸量不同：Fpl 不包含可检测到的唾液酸残基，而 Fp5 每个分子有四个唾液酸残基5。我们现在已经证明，AFP 分子中唾液酸残基的存在对于这种糖蛋白的免疫抑制活性至关重要。
AFP is the dominant serum protein in early embryonic life. It is considered also to be a tumour-associated antigen because it appears in the sera of patients and animals with primary liver cancer1. The function of AFP in the foetus remains unknown. Tomasi et al.2 have demonstrated that mouse AFP has an immunosuppressive effect on antibody synthesis both in vivo and in vitro. Similarly, human AFP has been reported to have immunosuippressive properties3. One of us (E.F.Z.) has sihown that mouse AFP is heterogeneous, consisting of five components (Fp1-Fp5)4, which differ in the amount of sialic acid attached to the molecule: Fpl contains no detectable sialyl residues while Fp5 has four per molecule5. We have now demonstrated that the presence of sialic acid residues in the AFP molecule is essential for the immunosuppressive activities of this glycoprotein.