Increase in [18F]-Fluoroacetate Uptake in Patients With Chronic Hemodynamic Cerebral Ischemia.
Increase in [18F]-Fluoroacetate Uptake in Patients With Chronic Hemodynamic Cerebral Ischemia.
复制标题
慢性血流动力学脑缺血患者[18F]-氟乙酸摄取增加。
DOI：
10.1161/strokeaha.115.010080
复制
发表时间：
2015
期刊：
影响因子：
8.3
通讯作者：
Higashi T.
中科院分区：
文献类型：
--
作者：
Yamauchi H;Kagawa S;Kishibe Y;Takahashi M;Nishii R;Mizuma H;Takahashi K;Onoe H;Higashi T.
背景与目的[18 F]-氟乙酸钠（18F-FACE）可用于评价胶质细胞代谢。实验研究表明，在啮齿动物模型的脑缺血中，18F-FACE摄取增加。本研究的目的是确定18F-FACE摄取是否增加，在非梗死大脑皮层的患者与血流动力学缺血，由于动脉粥样硬化颈内动脉或大脑中动脉diseases. Methods我们评估了9例症状性患者单侧动脉粥样硬化颈内动脉或大脑中动脉疾病和无皮质梗死使用正电子发射断层扫描与18F-FACE和15 O-气体。比较注射后40 ~ 60 min的FACE摄取与脑血流量、脑氧代谢率、氧摄取分数、结果脑缺血后，大脑中动脉同侧半球的脑血流量和脑氧代谢率明显降低，氧摄取分数和脑血容量明显增加病灶侧18F-FACE摄取明显高于对侧半球。相对18F-FACE摄取（同侧/对侧比值）与脑血流量或脑氧代谢率值呈负相关，与氧摄取分数值呈正相关。多因素分析显示，同侧/对侧18F-FACE摄取率与脑血流量独立相关（或氧提取分数）和脑氧代谢率值。结论在动脉粥样硬化性颈内动脉或大脑中动脉疾病患者中，18 F-慢性血流动力学缺血的非梗死大脑皮层FACE摄取增加，其特征是氧灌注减少新陈代谢.增加的18F-FACE摄取可能表明皮质区域处于缺血性损伤的特定风险中。
Background and Purpose[18F]-fluoroacetate (18F-FACE) can be used for evaluating glial cell metabolism. Experimental studies have shown an increase in18F-FACE uptake in rodent models of cerebral ischemia. The aim of this study was to determine whether18F-FACE uptake is increased in the noninfarcted cerebral cortex in patients with hemodynamic ischemia owing to atherosclerotic internal carotid artery or middle cerebral artery disease.MethodsWe evaluated 9 symptomatic patients with unilateral atherosclerotic internal carotid artery or middle cerebral artery disease and no cortical infarction using positron emission tomography with18F-FACE and15O-gases.18F-FACE uptake during 40 to 60 minutes after injection was compared with the cerebral blood flow, cerebral metabolic rate of oxygen, oxygen extraction fraction, and cerebral blood volume in the middle cerebral artery distributions.ResultsSignificant decreases of cerebral blood flow and cerebral metabolic rate of oxygen and increases of oxygen extraction fraction and cerebral blood volume were found in the hemisphere ipsilateral to the arterial lesion, and18F-FACE uptake in this region was greater than that in the contralateral hemisphere. The relative18F-FACE uptake (ipsilateral/contralateral ratio) was negatively correlated with cerebral blood flow or cerebral metabolic rate of oxygen values and was positively correlated with oxygen extraction fraction values. Multivariate analysis showed that the ipsilateral/contralateral18F-FACE uptake ratio was independently correlated with the cerebral blood flow (or oxygen extraction fraction) and cerebral metabolic rate of oxygen values.ConclusionsIn patients with atherosclerotic internal carotid artery or middle cerebral artery disease,18F-FACE uptake is increased in the noninfarcted cerebral cortex with chronic hemodynamic ischemia characterized by misery perfusion with decreased oxygen metabolism. Increased18F-FACE uptake may indicate the cortical regions that are at particular risk for ischemic damage.