iPSCs-Based Therapy for Trabecular Meshwork.
iPSCs-Based Therapy for Trabecular Meshwork.
复制标题
基于 iPSC 的小梁网治疗。
DOI：
10.1007/164_2023_671
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发表时间：
2023
影响因子：
--
通讯作者：
Kuehn,MarkusH
中科院分区：
文献类型：
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作者：
Zhu,Wei;Zhang,Xiaoyan;Wu,Shen;Wang,Ningli;Kuehn,MarkusH
眼小梁网（TM）是控制房水（AH）流出和眼内压（IOP）稳态的重要组织。然而，TM细胞功能失调和/或TM细胞数量减少已成为原发性开角型青光眼（POAG）的重要致病原因。因此，研究TM的特征是特别有价值的，这反过来又有助于开发新的POAG治疗方法。自2006年以来，诱导多能干细胞（iPSCs）的进展为(1)体外培养TM和(2)在POAG中再生退行性TM提供了新的工具。在此背景下，我们首先总结了目前从ipsc诱导TM样细胞分化的方法，并将ipsc衍生的TM模型与传统的体外TM模型进行了比较。还讨论了ipsc来源的TM细胞在POAG模型中再生TM的功效。通过这些方法，iPSCs正在成为青光眼建模和开发TM再生个性化治疗的重要工具。
The trabecular meshwork (TM) of the eye serves as an essential tissue in controlling aqueous humor (AH) outflow and intraocular pressure (IOP) homeostasis. However, dysfunctional TM cells and/or decreased TM cellularity is become a critical pathogenic cause for primary open-angle glaucoma (POAG). Consequently, it is particularly valuable to investigate TM characteristics, which, in turn, facilitates the development of new treatments for POAG. Since 2006, the advancement in induced pluripotent stem cells (iPSCs) provides a new tool to (1) model the TM in vitro and (2) regenerate degenerative TM in POAG. In this context, we first summarize the current approaches to induce the differentiation of TM-like cells from iPSCs and compare iPSC-derived TM models to the conventional in vitro TM models. The efficacy of iPSC-derived TM cells for TM regeneration in POAG models is also discussed. Through these approaches, iPSCs are becoming essential tools in glaucoma modeling and for developing personalized treatments for TM regeneration.