Mean gestation at delivery and histological chorioamnionitis correlates with early-onset neonatal sepsis following expectant management in pPROM
Mean gestation at delivery and histological chorioamnionitis correlates with early-onset neonatal sepsis following expectant management in pPROM
复制标题
DOI：
10.3109/01443615.2014.958143
复制
发表时间：
2015-04-01
影响因子：
1.3
通讯作者：
Gautam, V.
中科院分区：
文献类型：
--
作者：
Arora, P.;Bagga, R.;Gautam, V.
这项前瞻性观察性研究在印度进行，研究对象为100例妊娠26（0/7）- 33（0/7）周的早产胎膜破裂（pPROM）妇女，接受期待治疗，目的是将早发性新生儿败血症（EONS）与绒毛膜炎的各种特征相关联。在1.5年的研究期间，pPROM的发生率为7%。胎膜早破时的平均妊娠期为30（6/7）+/- 1.8周，分娩时为32（1/7）+/- 1周。在70/100名妇女中观察到临床、微生物、组织学或这些形式的绒毛膜炎特征。临床绒毛膜炎见于16%，宫颈拭子和胎盘膜培养中分别有30%和39%的细菌分离株，19%有组织学绒毛膜炎。23/97例（24%）存在EONS。未发现临床绒毛膜炎（p = 0.069）、宫颈拭子（p = 0.56）或胎盘膜（p = 0.39）上的细菌分离株可预测EONS;而组织学绒毛膜炎（p = 0.002）和分娩时较低的妊娠期（p = 0.013）与EONS显著相关。
This prospective observational study was carried out in India among 100 women with preterm pre-labour rupture of membranes (pPROM) between 26(0/7) - 33(0/7) weeks on expectant management in order to correlate early-onset neonatal sepsis (EONS) with various features of chorioamnionitis. The incidence of pPROM during the study period of 1.5 years was 7%. The mean gestation at pPROM was 30(6/7) +/- 1.8 weeks and at delivery was 32(1/7) +/- 1 weeks. Features of chorioamnionitis in the form of clinical, microbiological, histological or a combination of these were observed in 70/100 women. Clinical chorioamnionitis was seen in 16%, bacterial isolates were present in 30% on cervical swab and in 39% on placental membrane culture and 19% had histological chorioamnionitis. EONS was present in 23/97 (24%). Clinical chorioamnionitis (p = 0.069), bacterial isolates on cervical swab (p = 0.56) or placental membranes (p = 0.39) were not found to predict EONS; whereas histological chorioamnionitis (p = 0.002) and lower gestation at delivery (p = 0.013) were significantly associated with EONS.