[Leu13-ψ(CH2NH)Leu14]bombesin is a specific bombesin receptor antagonist in Swiss 3T3 cells
[Leu13-ψ(CH2NH)Leu14]bombesin is a specific bombesin receptor antagonist in Swiss 3T3 cells
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[Leu13-ψ(CH2NH)Leu14]bombesin 是瑞士 3T3 细胞中的特异性铃蟾肽受体拮抗剂
DOI：
10.1016/s0006-291x(88)81093-3
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发表时间：
1988
影响因子：
3.1
通讯作者：
E. Rozengurt
中科院分区：
文献类型：
--
作者：
P. Woll;D. Coy;E. Rozengurt
伪肽 [Leu13-ψ(CH2NH)Leu14]bombesin 以竞争性和可逆的方式阻断 Swiss 3T3 细胞中铃蟾肽刺激的有丝分裂发生，但其他有丝分裂剂则不然。它通过铃蟾肽样肽抑制细胞内 Ca2+ 的动员和蛋白激酶 C 的激活。它作用于受体水平，如抑制 [125I]GRP 结合和减少 Mr75-85,000 受体相关蛋白的交联所示。因此，[Leu13-ψ(CH2NH)Leu14]bombesin 是 Swiss 3T3 细胞中的特异性铃蟾肽受体拮抗剂，可阻断铃蟾肽样肽的长期生长促进作用。
The pseudopeptide [Leu13-ψ(CH2NH)Leu14]bombesin blocks bombesin-stimulated mitogenesis in Swiss 3T3 cells in a competitive and reversible manner, but not that of other mitogens. It inhibits the mobilization of intracellular Ca2+and activation of protein kinase C by bombesin-like peptides. It acts at receptor level, as shown by inhibition of [125I]GRP binding and reduction in cross-linking of the Mr75–85,000 receptor-associated protein. Thus [Leu13-ψ(CH2NH)Leu14]bombesin is a specific bombesin receptor antagonist in Swiss 3T3 cells which blocks long-term growth promoting effects of bombesin-like peptides.
影响因子：
15.9
作者：
SPINDEL, ER;SUNDAY, ME;CHIN, WW
通讯作者：
CHIN, WW