Metal-Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois' Reagent through Concomitant 1,2-Aryl Migration
Metal-Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois' Reagent through Concomitant 1,2-Aryl Migration
复制标题
使用 Langlois 试剂通过伴随 1,2-芳基迁移对烯丙醇进行无金属直接芳基三氟甲基化
DOI：
10.1002/ajoc.201500096
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发表时间：
2015-07-01
影响因子：
2.7
通讯作者：
Xia, Wujiong
中科院分区：
文献类型：
--
作者：
Huang, Hong-Li;Yan, Hang;Xia, Wujiong
通过级联三氟甲基自由基加成/1，2-芳基迁移反应，开发了一种无金属、经济有效的芳基三氟甲基化丙烯醇类化合物的合成方法。该方法具有操作简单、官能团耐受性好、反应条件温和等优点。
A metal-free and cost-effective synthetic protocol for selective aryltrifluoromethylation of allylic alcohols with Langlois' reagent (CF3SO2Na) through cascade trifluoromethyl radical addition/1,2-aryl migration has been developed. The highlights of this procedure are operational simplicity, excellent functional group tolerance, and mild reaction conditions.