Cytokines in host defense against Salmonella
Cytokines in host defense against Salmonella
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DOI：
10.1016/s1286-4579(01)01479-4
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发表时间：
2001-11-01
影响因子：
5.8
通讯作者：
Kagnoff, MF
中科院分区：
文献类型：
--
作者：
Eckmann, L;Kagnoff, MF
细胞因子是宿主细胞之间防御肠道病原体沙门氏菌的关键通讯分子。沙门氏菌感染诱导培养的肠上皮细胞和巨噬细胞表达多种趋化因子和促炎细胞因子。在动物模型中，IL-1 α、TNF α、IFN-γ、IL-12、IL-18和IL-15显示出保护作用，而IL-4和IL-10抑制宿主对沙门氏菌的防御。(C)2001年，Elsevier SAS科学与医学版。
Cytokines are key communication molecules between host cells in the defense against the enteric pathogen, Salmonella. Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages. In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella. (C) 2001 Editions scientifiques et medicales Elsevier SAS.