Metabolic neural mapping in neonatal rats
Metabolic neural mapping in neonatal rats
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新生大鼠的代谢神经图谱
DOI：
10.1002/jnr.490060103
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发表时间：
1981
影响因子：
4.2
通讯作者：
Warren G. Hall
中科院分区：
文献类型：
--
作者：
R. Dirocco;Warren G. Hall
在成年大鼠中通过14 C-脱氧葡萄糖放射自显影进行的功能性神经映射显示，与神经生理活性增加相关联的神经代谢率增加在轴突终末和树突中比在神经元细胞体中更明显。当神经元处于生理活性状态时，包含结构上明确定义的终末和树突（神经元）浓度的区域具有高代谢率。然而，在新生大鼠中，我们发现包含明确定义的神经元细胞体分组的区域在14 C-脱氧葡萄糖放射自显影图中具有高代谢率。从新生大鼠和成年大鼠获得的14 C-脱氧葡萄糖放射自显影图的形态学外观之间的显著差异可能与分化神经元的形态测量特征的发育变化以及所执行的神经工作的类型和位点的相关变化有关。
Functional neural mapping by 14C‐deoxyglucose autoradiography in adult rats has shown that increases in neural metabolic rate that are coupled to increased neurophysiological activity are more evident in axon terminals and dendrites than neuron cell bodies. Regions containing architectonically well‐defined concentrations of terminals and dendrites (neuropil) have high metabolic rates when the neuropil is physiologically active. In neonatal rats, however, we find that regions containing well‐defined groupings of neuron cell bodies have high metabolic rates in 14C‐deoxyglucose autoradiograms. The striking difference between the morphological appearance of 14C‐deoxyglucose autoradiograms obtained from neonatal and adult rats is probably related to developmental changes in morphometric features of differentiating neurons, as well as associated changes in type and locus of neural work performed.