Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
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DOI：
10.1359/jbmr.040103
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发表时间：
2004-04-01
影响因子：
6.2
通讯作者：
Kiel, DP
中科院分区：
文献类型：
--
作者：
Ferrari, SL;Karasik, D;Kiel, DP
生活方式和饮食因素可能影响IL-6基因多态性与骨量的关系。在1574名来自Frachial Offspring队列的无关男性和女性中，我们观察到仅在老年女性、不使用雌激素的女性和钙摄入量不足的女性中IL-6 - 174基因型之间的髋部BMD显著差异。因此，与BMD的IL-6多态性的关联可能仅限于离散的人口subgroup.Introduction：白细胞介素（IL）-6在骨质疏松症的发病机制中起着核心作用。IL-6启动子中的两个功能变体先前已与绝经后期妇女的IL-6表达、骨吸收水平和BMD相关，但结果在不同人群中相互矛盾。我们假设，IL-6启动子等位基因和BMD之间的关联可能会受到影响的相互作用与生活方式和饮食因素已知的影响bone turning.Materials和方法：在后代队列的心脏研究，1574无关的男性和女性的IL-6 - 572和-174等位基因。绝经后，雌激素状态，体力活动，吸烟，膳食钙，维生素D和酒精摄入量与年的相互作用分析的基础上BMD测量hip.Results和结论：在模型中，只考虑IL-6多态性的主要影响，没有显着的关联与BMD观察在任何性别。相比之下，在女性（n = 819）中观察到提示IL-6 - 174基因型与绝经后年数、雌激素状态、膳食钙和维生素D摄入之间的相互作用的p值（0.003-0.096，通过ANOVA）。反过来，在绝经15年以上的妇女和那些没有雌激素或钙摄入的妇女中，基因型-174 GG的BMD显著低于CC，而GC居中
Lifestyle and dietary factors may influence the association of IL-6 polymorphisms with bone mass. In 1574 unrelated men and women from the Framingham Offspring Cohort, we observed significant hip BMD differences between IL-6 -174 genotypes only in older women, those without estrogens, and those with a poor calcium intake. Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups.Introduction: Interleukin (IL)-6 plays a central role in the pathogenesis of osteoporosis. Two functional variants in the IL-6 promoter have previously been associated with IL-6 expression, bone resorption levels, and BMD in late postmenopausal women, but results were conflicting in different populations. We hypothesized that the association between IL-6 promoter alleles and BMD may be affected by interactions with lifestyle and dietary factors known to influence bone turnover.Materials and Methods: Among the Offspring Cohort of the Framingham Heart Study, 1574 unrelated men and women were genotyped for IL-6 -572 and -174 alleles. Interaction analyses with years since menopause, estrogen status, physical activity, smoking, dietary calcium, vitamin D, and alcohol intake were based on BMD measurements at the hip.Results and Conclusions: In models that considered only the main effects of IL-6 polymorphisms, no significant association with BMD was observed in either gender. In contrast, p values (0.003-0.096 by ANOVA) suggestive of an interaction between IL-6 -174 genotypes and years since menopause, estrogen status, dietary calcium, and vitamin D intake were observed in women (n = 819). In turn, BMD was significantly lower with genotype - 174 GG compared with CC, and intermediate with GC, in women who were more than 15 years past menopause and in those without estrogens or with calcium intake