Comparative analysis of the virulence characteristics of epidemic methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from Chinese children: ST59 MRSA highly expresses core gene-encoded toxin
Comparative analysis of the virulence characteristics of epidemic methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from Chinese children: ST59 MRSA highly expresses core gene-encoded toxin
复制标题
中国儿童流行性耐甲氧西林金黄色葡萄球菌（MRSA）毒力特征对比分析：ST59 MRSA高表达核心基因编码毒素
DOI：
10.1111/apm.12105
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发表时间：
2014-02-01
期刊：
影响因子：
2.8
通讯作者：
Shen, Xuzhuang
中科院分区：
文献类型：
--
作者：
Li, Shipeng;Sun, Jing;Shen, Xuzhuang
本研究旨在调查一种新的细胞壁锚定蛋白基因sasX的流行情况，并获得从中国儿童中分离的MRSA菌株致病潜力的遗传基础的信息。对临床分离菌株的分子生物学特性和毒力特性进行分析。共获得22种序列类型，其中流行性克隆ST 59、ST 239、ST 1、ST 910、ST 88和ST 338分别占35.8%、22%、6.6%、6.6%、5.3%和4.1%。hla、psm和RNAIII在ST 59中的表达水平高于其他ST（p
This study aims to investigate the prevalence of a novel cell wall-anchored protein gene, sasX, and to obtain information on the genetic basis for the pathogenic potential of the MRSA strains isolated from Chinese children. The molecular and virulence characteristics of the clinical strains were analyzed. Twenty-two sequence types (STs) were obtained, with six epidemic clones ST59, ST239, ST1, ST910, ST88, and ST338 accounting for 35.8, 22, 6.6, 6.6, 5.3, and 4.1% respectively. The expression levels of hla, psm, and RNAIII were higher in ST59 than in other STs (p