The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease
The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease
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DOI：
10.1111/apt.12208
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发表时间：
2013-03-01
影响因子：
7.6
通讯作者：
Fox, M.
中科院分区：
文献类型：
--
作者：
Anggiansah, R.;Sweis, R.;Fox, M.
背景肥胖患者发生胃食管反流病的风险增加;然而，这种相关性的机制尚不确定。目的验证肥胖对食管功能的机械作用增加酸暴露和症状的假设。方法对有典型反流症状的食管反流患者行食管测压和24 h pH监测，测量身高、体重和腰围（WC）。通过问卷调查评估症状严重程度。评估肥胖[WC，体重指数（BMI）]，食管功能，酸暴露和反流症状之间的关系。结果582例患者（中位年龄48岁，56%为女性），其中406例（70%）完成了症状问卷。女性肥胖患病率较高（BMI 30 kg/m2;女性23%：男性16%; P=0.056），而男性肥胖患病率较高（WC 99 cm（男性41%：女性28%; P=0.001））。食管酸暴露随肥胖而增加（WC：R=0.284，P
Background Obese patients have an increased risk of gastro-oesophageal reflux disease; however, the mechanism underlying this association is uncertain. Aim To test the hypothesis that mechanical effects of obesity on oesophageal function increase acid exposure and symptoms. Methods Height, weight and waist circumference (WC) were measured in patients with typical reflux symptoms referred for manometry and 24h ambulatory pH studies. Symptom severity was assessed by questionnaire. The association between obesity [WC, body mass index (BMI)], oesophageal function, acid exposure and reflux symptoms was assessed. Results Physiological measurements were obtained from 582 patients (median age 48, 56% female) of whom 406 (70%) completed symptom questionnaires. The prevalence of general obesity was greater in women (BMI30kg/m2; F 23%:M 16%; P=0.056), however more men had abdominal obesity (WC99 cm (M 41%:F 28%; P=0.001)). Oesophageal acid exposure increased with obesity (WC: R=0.284, P