Urinary Trypsin Inhibitor Attenuated Inflammatory Response of Patients Undergoing Cardiopulmonary Bypass by Inducing Activated Treg Cells
Urinary Trypsin Inhibitor Attenuated Inflammatory Response of Patients Undergoing Cardiopulmonary Bypass by Inducing Activated Treg Cells
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尿胰蛋白酶抑制剂通过诱导激活的 Treg 细胞减轻体外循环患者的炎症反应
DOI：
10.1007/s10753-013-9666-3
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发表时间：
2013-12-01
期刊：
影响因子：
5.1
通讯作者：
Hou, Xiaotong
中科院分区：
文献类型：
--
作者：
Hao, Xing;Han, Junyan;Hou, Xiaotong
尿胰蛋白酶抑制剂（乌司他丁）用于临床预防体外循环（CPB）患者的炎症反应；然而，其抗炎机制尚不清楚。在目前的研究中，我们招募了40名接受选择性心脏瓣膜置换术的患者；将患者随机分为乌司他汀组[UG]和对照组[CG]。我们在术前、CPB结束时和术后第1天和第3天采集外周血，分析调节性T （Treg）细胞亚群的动力学变化。两组患者CD4+T细胞数量比较，差异无统计学意义。UG组CD4+CD25+Treg细胞，尤其是抑制性活化Treg （aTreg）亚群的数量在术后1和3 d高于CG组。因此，乌司他丁通过诱导aTreg细胞的扩增来减轻CPB期间的炎症反应。
The urinary trypsin inhibitor (ulinastatin) is used in the clinic to prevent inflammatory responses in patients undergoing cardiopulmonary bypass (CPB); however, the anti-inflammatory mechanism is unclear. In the current study, we recruited 40 patients undergoing selective cardiac valve replacement surgery; and these patients were randomly divided into two groups (ulinastatin group [UG] and control group [CG]). We collected peripheral blood preoperatively, at the end of CPB, and postoperative days 1 and 3 and analyzed the kinetic changes in regulatory T (Treg) cell subsets. There was no statistically significant difference in the number of CD4+T cells between the two groups. The number of CD4+CD25+Treg cells, especially the suppressive activated Treg (aTreg) subset, was higher in the UG than the CG 1 and 3 days postoperatively. Thus, ulinastatin alleviated the inflammatory response during CPB by inducing the expansion of aTreg cells.