Bone scintigraphy and SPECT in the evaluation of the osseointegrative response to immediate prosthetic loading of endosseous implants: a pilot study.
Bone scintigraphy and SPECT in the evaluation of the osseointegrative response to immediate prosthetic loading of endosseous implants: a pilot study.
复制标题
骨闪烁扫描和 SPECT 评估骨内植入物即时假体负载的骨整合反应：一项试点研究。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
L. Lo Muzio
中科院分区：
文献类型：
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作者：
F. Bambini;L. Memè;M. Procaccini;B. Rossi;L. Lo Muzio
目的
最近的一些医学报告集中注意力在可能的应用，骨骼肌造影成像在口腔医学。本报告的目的是通过骨密度图评估即刻假体负载对种植体周围成骨细胞活性的影响。
材料和方法
植入2名健康女性。在种植体植入后30天和90天，对两名患者进行了单光子发射型计算机断层扫描（SPECT）核医学调查。该研究通过采集颅骨前视图中的平面图像以及在对应于即刻载荷的区域和对侧半下颌骨（对照部位）中使用相同大小的感兴趣区域（ROI）完成。从每个ROI获得的计数密度比（计数/像素）用于定量/相对评估。用定性方法评价断层图像。重建的断层图像和平面图像的空间分辨率约为7 mm。
结果
常规平面方法提供了检查区域细胞活性的直接测量。从第一次和第二次骨密度成像之间的相同ROI记录的计数密度比的差异揭示了种植体周围成骨细胞活性的过程，其在第一个月非常高，然后在随后的几个月内下降。
讨论和结论
尽管涉及的患者数量较少，但从这项初步研究中获得的结果表明，对于那些寻求澄清成骨细胞活性仍未知方面的人来说，核医学可能在种植牙科中具有潜在的优势。
PURPOSE
Several recent medical reports have focused attention on the possible application of skeletal scintigraphy imaging in odontostomatology. The aim of the present report was to assess the influence of immediate prosthetic loading on peri-implant osteoblastic activity through bone scintigraphy.
MATERIALS AND METHODS
Implants were placed in 2 healthy women. A nuclear medicine investigation with single-photon emission-computed tomography (SPECT) was performed for both patients at 30 and 90 days after implant placement. The study was completed with acquisitions of planar images of the skull in an anterior view and the use of regions of interest (ROIs) of the same size in the area corresponding to immediate loading and in the opposite hemimandible (at the control sites). Count density ratios (counts/pixel) obtained from each ROI were used for a quantitative/relative assessment. Tomographic images were evaluated with a qualitative method. The spatial resolution of the reconstructed tomograms and of the planar images was approximately 7 mm.
RESULTS
Routine planar methodology provided a direct measure of cellular activity of the examined areas. The difference in count density ratio registered from the same ROI between the first and the second scintigraphy revealed the course of peri-implant osteoblastic activity, which was very high in the first month and then declined during subsequent months.
DISCUSSION AND CONCLUSION
In spite of the small number of involved patients, the results obtained from this pilot study suggest that nuclear medicine may hold possible advantages in implant dentistry for those who seek to clarify the still unknown aspects of osteoblastic activity.