Smallpox vaccine does not protect Macaques with AIDS from a lethal Monkeypox virus challenge
Smallpox vaccine does not protect Macaques with AIDS from a lethal Monkeypox virus challenge
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DOI：
10.1086/427265
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发表时间：
2005-02-01
影响因子：
6.4
通讯作者：
Franchini, G
中科院分区：
文献类型：
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作者：
Edghill-Smith, Y;Bray, M;Franchini, G
目前还不清楚天花疫苗接种是否会保护人类免疫缺陷病毒1型（HIV-1）感染的个体，因为辅助CD 4（+）细胞，HIV-1感染的目标，是诱导适应性CD 8（+）细胞和B细胞反应所必需的。我们已经在猕猴中解决了这个问题，并且已经证明，尽管在免疫缺陷猕猴中接种天花疫苗是安全的，但在免疫之前先用高度减毒的牛痘病毒株进行免疫，如果猕猴的CD 4（+）细胞计数低于
It is unknown whether smallpox vaccination would protect human immunodeficiency virus type 1 (HIV-1) infected individuals, because helper CD4(+) cells, the targets of HIV-1 infection, are necessary for the induction of both adaptive CD8(+) cell and B cell responses. We have addressed this question in macaques and have demonstrated that, although smallpox vaccination is safe in immunodeficient macaques when it is preceded by immunization with highly attenuated vaccinia strains, the macaques were not protected against lethal monkeypox virus challenge if their CD4(+) cell count was