Can preoperative computed tomography predict tissue origin of primary maxillary cancer?
Can preoperative computed tomography predict tissue origin of primary maxillary cancer?
复制标题
术前计算机断层扫描可以预测原发性上颌骨癌的组织起源吗？
DOI：
10.1097/md.0000000000004831
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发表时间：
2016-10
期刊：
影响因子：
1.6
通讯作者：
Tao X
中科院分区：
文献类型：
--
作者：
Yuan Y;Wang J;Wu Y;Li G;Tao X
摘要上颌恶性肿瘤在其组织病理学来源上，虽有一些共同的临床特征，但其生物学行为、治疗及预后却各不相同。本研究旨在探讨原发性上颌窦癌（MC）的CT表现与其组织来源的关系。对2005年1月1日至2013年12月31日诊断为MC的患者的CT结果进行了回顾性审查。进行单变量和多变量逻辑回归分析，以确定组织来源和CT特征之间的关联，并对可能的混杂因素进行调整。共纳入164例患者（70例男性，94例女性，年龄：46.8 ± 18.3岁）。 患者分为上皮性（n = 88）和非上皮性（n = 76），或牙源性（n = 15）和非牙源性（n = 149）组。 在多变量logistic回归模型中调整年龄、性别、吸烟状况、饮酒、肿瘤大小和分期后，发现皮质弯曲病变更可能是上皮性的（比值比[OR]= 7.0，95%置信区间[CI]，1.4-36.1）而不是非上皮性的，而颈部淋巴结病病变更可能与非牙源性的起源（OR = 12.6，95% CI，1.1-140.0）而不是牙源性的。 在上皮癌中，皮质弯曲的病变是唾液腺型的14倍（OR = 13.8，95%CI，1.3-141.5）。 皮质弯曲和颈部淋巴结肿大的CT特征可能提示MC的组织起源。更大规模的前瞻性研究是必要的，以进一步研究这种关联。
AbstractBased on the histopathologic origin, malignant maxillary neoplasms may share some clinical characteristics but have different biological behavior, treatments, and prognoses. The aim of the present study was to explore the association between CT characteristics and tissue origin of primary maxillary cancer (MC). A retrospective review of CT findings was performed in patients diagnosed with MC between January 1, 2005 and December 31, 2013. Univariate and multivariable logistic regression analyses were performed to determine the association between tissue of origin and CT characteristics, with adjustment for possible confounding factors. A total of 164 patients (70 male, 94 female, age: 46.8 ± 18.3 years) were included. Patients were divided into epithelial (n = 88) and nonepithelial (n = 76), or odontogenic (n = 15) and nonodontogenic (n = 149) groups. After adjusting for age, sex, smoking status, alcohol use, tumor size, and stage in the multivariable logistic regression model, the lesions with cortical bowing were found more likely to be epithelial (odds ratio [OR] = 7.0, 95% confidence interval [CI], 1.4–36.1) than nonepithelial origin, while lesions with cervical lymphadenopathy were more associated with a nonodontogenic origin (OR = 12.6, 95% CI, 1.1–140.0) rather than odontogenic. Among epithelial cancers, lesions with cortical bowing were 14 times more likely to be salivary gland-type (OR = 13.8, 95% CI, 1.3–141.5). CT characteristics of cortical bowing and cervical lymphadenopathy might be suggestive of tissue origin in MC. Larger prospective studies are warranted to further examine the association.