Imaging putative foetal cerebral blood oxygenation using susceptibility weighted imaging (SWI).
Imaging putative foetal cerebral blood oxygenation using susceptibility weighted imaging (SWI).
复制标题
使用磁敏加权成像 (SWI) 对假定的胎儿脑血氧饱和度进行成像。
DOI：
10.1007/s00330-017-5160-x
复制
发表时间：
2018
影响因子：
5.9
通讯作者：
Neelavalli,Jaladhar
中科院分区：
文献类型：
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作者：
Yadav,BrijeshKumar;Krishnamurthy,Uday;Buch,Sagar;Jella,Pavan;Hernandez-Andrade,Edgar;Yeo,Lami;Korzeniewski,StevenJ;Trifan,Anabela;Hassan,SoniaS;Haacke,EMark;Romero,Roberto;Neelavalli,Jaladhar
目的评估妊娠中期和晚期正常人类胎儿的磁化率 Δχv 作为静脉血氧饱和度 (SvO2) 的替代指标。方法对 36 名平均孕龄 (GA) 为 31 2/7 周的孕妇进行磁共振成像 (MRI)。获取胎儿大脑的磁敏感加权成像（SWI）数据。使用 MR 敏感度测量法根据血管内相位测量对上矢状窦 (SSS) 的 Δχv 进行量化。假设胎儿血液的磁特性 Δχdo 与成人血液的磁特性相同，则 SvO2 由测量的 Δχv 得出。对作为 GA 函数的 Δχvan 和 SvO2 的变化进行了统计评估。结果发现，妊娠中期胎儿 (n= 8) 和妊娠晚期胎儿 (n= 28) 的 SSS 平均值 Δχvin 分别为 0.34±0.06 ppm 和 0.49 ±0.05 ppm。相应地，导出的 SvO2 值为 69.4% ±3.27% 和 62.6% ±3.25%。虽然没有统计学意义，但观察到随着妊娠的进展，Δχv 呈增加趋势 (p= 0.08)，SvO2 呈下降趋势 (p= 0.22)。结论我们报告了健康人类胎儿的脑静脉血磁化率和推定的氧饱和度。健康人类胎儿的脑氧饱和度尽管有轻微下降的趋势，但不会随着妊娠的推进而发生显着变化。要点• 人类胎儿的脑静脉磁化率和氧合可以量化。• 妊娠中期和晚期胎儿的脑静脉氧合没有差异。• 胎儿脑静脉氧合不会随着妊娠的推进而发生显着变化。
ObjectiveTo evaluate the magnetic susceptibility, ∆χv, as a surrogate marker of venous blood oxygen saturation, SvO2, in second- and third-trimester normal human foetuses.MethodsThirty-six pregnant women, having a mean gestational age (GA) of 31 2/7 weeks, underwent magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) data from the foetal brain were acquired. ∆χvof the superior sagittal sinus (SSS) was quantified using MR susceptometry from the intra-vascular phase measurements. Assuming the magnetic property of foetal blood, ∆χdo, is the same as that of adult blood, SvO2was derived from the measured Δχv. The variation of ∆χvand SvO2, as a function of GA, was statistically evaluated.ResultsThe mean ∆χvin the SSS in the second-trimester (n= 8) and third-trimester foetuses (n= 28) was found to be 0.34± 0.06 ppm and 0.49 ±0.05 ppm, respectively. Correspondingly, the derived SvO2values were 69.4% ±3.27% and 62.6% ±3.25%. Although not statistically significant, an increasing trend (p= 0.08) in Δχvand a decreasing trend (p= 0.22) in SvO2with respect to advancing gestation was observed.ConclusionWe report cerebral venous blood magnetic susceptibility and putative oxygen saturation in healthy human foetuses. Cerebral oxygen saturation in healthy human foetuses, despite a slight decreasing trend, does not change significantly with advancing gestation.Key points• Cerebral venous magnetic susceptibility and oxygenation in human foetuses can be quantified.• Cerebral venous oxygenation was not different between second- and third-trimester foetuses.• Foetal cerebral venous oxygenation does not change significantly with advancing gestation.