Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.
Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.
复制标题
DOI：
10.1016/j.brainres.2011.11.003
复制
发表时间：
2012-01-11
期刊：
影响因子：
2.9
通讯作者：
Malanga CJ
中科院分区：
文献类型：
--
作者：
Riday TT;Fish EW;Robinson JE;Jarrett TM;McGuigan MM;Malanga CJ
下丘脑神经肽的增食欲素家族参与了与食物和药物奖赏相关的强化机制。以前对食欲素A选择性受体OX1拮抗剂的行为学研究表明，OX1参与了行为敏感化、条件性位置偏爱和药物滥用的自我给药。成年雄性Swiss-Webster小鼠在下丘脑外侧植入刺激电极，进行脑内自我刺激(ICSS)训练。观察氧合酶1选择性拮抗剂SB 334867对脑刺激奖赏效应和可卡因增强效应的影响。SB 334867(10-30 mg/kg，ip)单独使用对ICSS性能或BSR阈值没有影响。可卡因(1.0-30 mg/kg ip)剂量依赖地增强BSR，测量为BSR阈值的降低。这种作用不能被30 mg/kg SB-334867在任何可卡因剂量下阻断。与以前的报告一致，SB 334867在急性给药24小时后导致体重减轻。基于这些数据，我们得出结论：作用于OX1的食欲素不参与BSR；也不参与可卡因对BSR的奖赏增强作用。这些数据是在先前关于SB 334867对药物寻找和药物消费行为的影响的发现的背景下讨论的。
The orexin family of hypothalamic neuropeptides has been implicated in reinforcement mechanisms relevant to both food and drug reward. Previous behavioral studies with antagonists at the orexin A-selective receptor, OX1, have demonstrated its involvement in behavioral sensitization, conditioned place-preference, and self-administration of drugs of abuse. Adult male Swiss-Webster mice were implanted with stimulating electrodes to the lateral hypothalamus and trained to perform intracranial self-stimulation (ICSS). The effects of the OX1-selective antagonist SB 334867 on brain stimulation-reward (BSR) and cocaine potentiation of BSR were measured. SB 334867 (10 – 30 mg/kg, i.p.) alone had no effect on ICSS performance or BSR threshold. Cocaine (1.0 – 30 mg/kg i.p.) dose-dependently potentiated BSR, measured as lowering of BSR threshold. This effect was not blocked by 30 mg/kg SB 334867 at any cocaine dose tested. In agreement with previous reports, SB 334867 resulted in a reduction of body weight 24 hours after acute administration. Based on these data, it is concluded that orexins acting at OX1 do not contribute to BSR; and are not involved in the reward-potentiating actions of cocaine on BSR. The data are discussed in the context of prior findings of SB 334867 effects on drug-seeking and drug-consuming behaviors.
登录
查看更多内容
影响因子：
--
作者：
Haynes, AC;Jackson, B;Arch, JRS
通讯作者：
Arch, JRS
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
4.8
作者：
Clegg, DJ;Air, EL;Seeley, RJ
通讯作者：
Seeley, RJ
DOI：
10.1073/pnas.0808023105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Hollander, Jonathan A.;Lu, Qun;Kenny, Paul J.
通讯作者：
Kenny, Paul J.