Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D-phenylalanine.
Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D-phenylalanine.
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由D-苯丙氨酸合成硫酸右旋苯丙胺和盐酸甲基苯丙胺。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
W. J. Ferguson
中科院分区：
文献类型：
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作者：
D. B. Repke;D. K. Bates;W. J. Ferguson
以D-苯丙氨酸为原料，合成了硫酸右苯丙胺和盐酸甲基苯丙胺。反应顺序经过三个中间体，其中不对称碳原子的绝对构型发生变化，但相对构型保持不变。通过改变用于去除氨基甲酸酯保护基团的还原条件，可以从常见的中间体获得任一产物。
Starting from D-phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three intermediates, in which the absolute configuration of the asymmetric carbon atom is changed but the relative configuration remains the same. Either product can be obtained from a common intermediate by altering the reductive conditions employed for the removal of a carbamate protecting group.