Chronic sucrose intake augments antinociception induced by injections of mu but not kappa opioid receptor agonists into the periaqueductal gray matter in male and female rats
Chronic sucrose intake augments antinociception induced by injections of mu but not kappa opioid receptor agonists into the periaqueductal gray matter in male and female rats
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DOI：
10.1016/s0006-8993(01)03039-6
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发表时间：
2001-11-30
期刊：
影响因子：
2.9
通讯作者：
Wiatr, C
中科院分区：
文献类型：
--
作者：
Kanarek, RB;Mandillo, S;Wiatr, C
长期摄入可口的蔗糖溶液可增强全身给药的 mu 和 kappa 阿片受体激动剂的抗伤害效力。为了研究蔗糖对阿片类药物作用的影响是否是在中枢神经系统 (CNS) 内介导的，在导水管周围灰色区域 (PAG) 施用 mu 和 kappa 阿片类受体激动剂后，检查了镇痛作用。雄性和雌性 Long-Evans 大鼠消耗水和磨碎的食物，或者水、食物和 32% (w/v) 蔗糖溶液。适应饮食条件后，将引导插管立体定向植入 PAG 中。在雄性和雌性大鼠的甩尾试验中，将 mu 激动剂吗啡（0.0、2.5、5.0、10.0 和 20.0 杯）注射到 PAG 中，会导致剂量相关的镇痛反应增加。食用蔗糖的大鼠比未摄入糖的大鼠表现出明显更高水平的抗伤害作用。对吗啡的镇痛反应不因性别而异。将 kappa 激动剂螺旋多林（0、100、300、600 杯）注射到 PAG 中会增加雄性和雌性大鼠的甩尾潜伏期。然而，注射螺旋多林的大鼠的抗伤害反应并没有随着饮食的变化而变化。在两种饮食条件下，螺旋多林对雌性大鼠的镇痛作用均高于雄性大鼠。这些结果支持这样的假设：摄入可口的食物和液体会在中枢神经系统内发挥作用，以调节阿片类药物的行为作用。 (C) 2001 年爱思唯尔科学 BY。版权所有。
Chronic intake of a palatable sucrose solution enhances the antinociceptive potency of systemically administered mu, and kappa opioid receptor agonists. To investigate whether the effects of sucrose on the actions of opioid drugs are mediated within the central nervous system (CNS), antinociception was examined following the administration of mu and kappa opioid receptor agonists into the periaqueductal gray area (PAG). Male and female Long-Evans rats consumed either water and ground chow, or water, chow and a 32% (w/v) sucrose solution. After adaptation to the dietary conditions, a guide cannula was stereotaxically implanted into the PAG. Injections of the mu agonist, morphine (0.0, 2.5, 5.0, 10.0 and 20.0 mug), into the PAG led to dose-related increases in antinociceptive responses on a tail flick test in both male and female rats. Rats which had consumed sucrose displayed significantly greater levels of antinociception than rats not given the sugar. Antinociceptive responses to morphine did not differ as a function of sex. Injections of the kappa agonist, spiradoline (0, 100, 300, 600 mug), into the PAG increased tail flick latencies in male and female rats. However, antinociceptive responses did not vary as a function of diet in rats injected with spiradoline. In both diet conditions, spiradoline led to greater levels of antinociception in female rats than in male rats. These results support the hypothesis that intake of palatable foods and fluids act within the CNS to moderate the behavioral actions of opioid drugs. (C) 2001 Elsevier Science BY. All rights reserved.