2,2-Dialkylnaphthalen-1-ones as new potassium channel activators.
2,2-Dialkylnaphthalen-1-ones as new potassium channel activators.
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2,2-二烷基萘-1-酮作为新型钾通道激活剂。
DOI：
10.1021/jm00067a011
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发表时间：
1993
影响因子：
7.3
通讯作者：
J. Forn
中科院分区：
文献类型：
--
作者：
C. Almansa;L. Gomez;F. Cavalcanti;R. Rodriguez;E. Carceller;J. Bartrolí;J. García;J. Forn
A new series of 2,2-dialkylnaphthalen-1-one potassium channel activators has been prepared, and their in vitro relaxant activities in isolated rat portal vein and guinea pig tracheal spirals as well as their oral antihypertensive effect in spontaneously hypertensive rats have been evaluated. The group of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethylnaphthalen -1- ones with an electron-withdrawing substituent at the 6-position contain the most active compounds and 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphtha lene-6- carbonitrile, 17f (UR-8225), has been selected for further pharmacological development.
