Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.
Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.
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DOI：
10.1161/atvbaha.111.241869
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Shoelson SE
中科院分区：
文献类型：
--
作者：
Romeo GR;Lee J;Shoelson SE
肥胖及其合并症，包括2型糖尿病（T2D）和心血管疾病（CVD），与慢性低度炎症状态相关，可以在全身和特定组织中检测到。活跃的研究领域集中在“代谢性”炎症的分子基础和在胰岛素抵抗、T2D和CVD中的潜在致病作用。在肥胖脂肪组织中发生的巨噬细胞积累增加已经成为“代谢”炎症的关键过程。最近的研究也开始揭示脂肪组织巨噬细胞的异质性，以及它们与脂肪组织微环境中的脂肪细胞、内皮细胞和其他免疫细胞的物理和功能相互作用。将胰岛素抵抗和T2D实验模型中收集的信息转化为有意义的治疗干预措施是一个具有长期全球健康影响的诱人目标。在这种情况下，正在进行的临床研究正在测试全身靶向炎症对代谢和心血管结局的影响。
Obesity and its co-morbidities, including type 2 diabetes (T2D) and cardiovascular disease (CVD), are associated with a state of chronic low-grade inflammation that can be detected both systemically and within specific tissues. Areas of active investigation focus on the molecular bases of ‘metabolic’ inflammation and potential pathogenic roles in insulin resistance, T2D and CVD. An increased accumulation of macrophages occurring in obese adipose tissue has emerged as a key process in ‘metabolic’ inflammation. Recent studies have also begun to unravel the heterogeneity of adipose tissue macrophages, and their physical and functional interactions with adipocytes, endothelial cells and other immune cells within the adipose tissue microenvironment. Translating the information gathered in experimental models of insulin resistance and T2D into meaningful therapeutic interventions is a tantalizing goal with long-term global health implications. In this context, ongoing clinical studies are testing the effects of targeting inflammation systemically on metabolic and cardiovascular outcomes.