Non-verbal auditory cognition in patients with temporal epilepsy before and after anterior temporal lobectomy
Non-verbal auditory cognition in patients with temporal epilepsy before and after anterior temporal lobectomy
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DOI：
10.3389/neuro.09.042.2009
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发表时间：
2009-11-01
影响因子：
2.9
通讯作者：
Bertrand, Olivier
中科院分区：
文献类型：
--
作者：
Bidet-Caulet, Aurelie;Ye, Xiao Lai;Bertrand, Olivier
对于药物耐药性颞叶癫痫患者，单侧前颞叶切除术（ATL）-即海马、杏仁核、颞极和颞回最前部的手术切除-是一种有效的治疗方法。越来越多的证据表明，颞叶前部区域参与了与物体相关的声音特性的整合和短期记忆。然而，颞叶癫痫（TLE）患者的非言语听觉处理却很少受到关注。为了评估颞叶癫痫患者单侧ATL前后的非语言听觉认知，我们开发了一套包括环境声音在内的非语言听觉测试。我们可以评估听觉语义识别，声学和物体相关的短期记忆，以及从声音混合物中提取声音。将26例TLE患者在ATL之前和/或之后的表现与18名健康受试者的表现进行比较。ATL之前和之后的患者被发现存在类似的缺陷，在音高保持，识别和短期记忆的环境声音，而不是受损的基本声学处理相比，健康受试者。这是最有可能的，在ATL之前和之后观察到的缺陷与癫痫神经病理过程。因此，在耐药TLE患者中，ATL似乎可以显著改善癫痫发作控制，而不会产生额外的听觉缺陷。
For patients with pharmaco-resistant temporal epilepsy, unilateral anterior temporal lobectomy (ATL) - i.e. the surgical resection of the hippocampus, the amygdala, the temporal pole and the most anterior part of the temporal gyri - is an efficient treatment. There is growing evidence that anterior regions of the temporal lobe are involved in the integration and short-term memorization of object-related sound properties. However, non-verbal auditory processing in patients with temporal lobe epilepsy (TLE) has raised little attention. To assess non-verbal auditory cognition in patients with temporal epilepsy both before and after unilateral ATL, we developed a set of non-verbal auditory tests, including environmental sounds. We could evaluate auditory semantic identification, acoustic and object-related short-term memory, and sound extraction from a sound mixture. The performances of 26 TLE patients before and/or after ATL were compared to those of 18 healthy subjects. Patients before and after ATL were found to present with similar deficits in pitch retention, and in identification and short-term memorisation of environmental sounds, whereas not being impaired in basic acoustic processing compared to healthy subjects. It is most likely that the deficits observed before and after ATL are related to epileptic neuropathological processes. Therefore, in patients with drug-resistant TLE, ATL seems to significantly improve seizure control without producing additional auditory deficits.