DESIGN OF LIPOSOMES FOR ENHANCED LOCAL RELEASE OF DRUGS BY HYPERTHERMIA
DESIGN OF LIPOSOMES FOR ENHANCED LOCAL RELEASE OF DRUGS BY HYPERTHERMIA
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DOI：
10.1126/science.364652
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
BLUMENTHAL, R
中科院分区：
文献类型：
--
作者：
YATVIN, MB;WEINSTEIN, JN;BLUMENTHAL, R
脂质体可以被设计成在温和的局部热疗所能达到的温度下优先释放被包裹的药物。在体外测试系统中，通过将含有新霉素的脂质体加热到其相变温度以最大限度地释放药物，抑制了大肠杆菌的蛋白质合成，并增强了对细胞的杀伤力。在有血清存在的情况下，44度时的释放率。华氏37度。C可以大于100：1，这表明可能在肿瘤或局部感染的治疗中应用。
Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44.degree. C to that at 37.degree. C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.