Stable phantom materials for ultrasound and optical imaging
Stable phantom materials for ultrasound and optical imaging
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DOI：
10.1088/1361-6560/62/2/432
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发表时间：
2017-01-21
影响因子：
3.5
通讯作者：
Pavan, Theo Z.
中科院分区：
文献类型：
--
作者：
Cabrelli, Luciana C.;Pelissari, Pedro I. B. G. B.;Pavan, Theo Z.
模拟生物组织的特定特性是充分表征医疗器械的关键。水基材料通常用于制造用于超声和光学成像技术的体模。然而，这些材料具有缺点，例如容易降解和时间稳定性低。在这项研究中，我们提出了一种基于油的新型组织模拟材料，用于超声和光学成像，具有时间降解低的优点。在矿物油样品中制备苯乙烯-乙烯/丁烯-苯乙烯（SEBS）共聚物，SEBS浓度在5%-15%之间变化，低密度聚乙烯（LDPE）在0%-9%之间变化。声学特性，如声速和衰减系数，获得使用的频率范围从1-10 MHz，并与软组织的一致。通过改变SEBS和LDPE浓度来控制这些性质。为了表征样品的光学性质，测量漫反射率和透射率。计算每种化合物在400 nm-1200 nm范围内的散射和吸收系数。SEBS凝胶是一种半透明材料，在光谱的可见光区具有低的光吸收和散射系数，但LDPE的存在增加了浊度。添加LDPE增加了体模材料的吸收和散射。获得了由LDPE/SEBS制成的含有球形夹杂物的异质体模的超声和光声图像。在包合物中加入胭脂树红染料以提高其吸光度。结果表明，共聚物凝胶是有前途的超声和光学成像，使它们也有可能用于光声成像。
Phantoms mimicking the specific properties of biological tissues are essential to fully characterize medical devices. Water-based materials are commonly used to manufacture phantoms for ultrasound and optical imaging techniques. However, these materials have disadvantages, such as easy degradation and low temporal stability. In this study, we propose an oil-based new tissue-mimicking material for ultrasound and optical imaging, with the advantage of presenting low temporal degradation. A styrene-ethylene/butylene-styrene (SEBS) copolymer in mineral oil samples was made varying the SEBS concentration between 5%-15%, and low-density polyethylene (LDPE) between 0%-9%. Acoustic properties, such as the speed of sound and the attenuation coefficient, were obtained using frequencies ranging from 1-10 MHz, and were consistent with that of soft tissues. These properties were controlled varying SEBS and LDPE concentration. To characterize the optical properties of the samples, the diffuse reflectance and transmittance were measured. Scattering and absorption coefficients ranging from 400 nm-1200 nm were calculated for each compound. SEBS gels are a translucent material presenting low optical absorption and scattering coefficients in the visible region of the spectrum, but the presence of LDPE increased the turbidity. Adding LDPE increased the absorption and scattering of the phantom materials. Ultrasound and photoacoustic images of a heterogeneous phantom made of LDPE/SEBS containing a spherical inclusion were obtained. Annatto dye was added to the inclusion to enhance the optical absorbance. The results suggest that copolymer gels are promising for ultrasound and optical imaging, making them also potentially useful for photoacoustic imaging.